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It is accepted today that cytotoxic drugs are the only remittent agents in posterior uveitis (PU) and retinal vasculitis (RV) of Behcet's disease (BD). The important question is which cytotoxic is the most effective and the least harmful. We compare here the results of 3 efficient methods of cytotoxic therapy with the same mean follow-up time of 12 months: IV Pulse Cyclophosphamide (PCP) in 121 patients, weekly low dose Methotrexate (MTX) in 95 patients and Cyclosporine A (CYA) in 16 patients. All the patients received prednisolone 0.5 mg/kg/d. Improvement or stabilization of he lesions for each section of the eyes or visual acuity (VA) were accepted as a good result. In anterior uveitis the good result was 77%(CI= 6.8) with PCP, 74%(CI= 8.2) with MTX and 88%(CI= 15.4) with CYA. For PU the good result was 82%(CI= 5.6) with PCP, 87%(CI= 5.4) with MTX and 100% with CYA. In RV the good results was 73%(CI= 7.5 …