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The neuropsychiatric manifestations of systemic lupus erythematosus are frequent. One of the most serious presentations is convulsion. This study was carried out to evaluate the relation between convulsion and anti-DNA antibody levels. An analytic, retrospective case-controlled study was carried out, with reference to 1001 recorded cases of systemic SLE lupus erythematosus in Lupus Unit, Rheumatology Center, Shariati Hospital, Tehran University of Medical Sciences. Thefrequency of convulsion was 13.3%. There was no significant difference in the frequency of convulsoin inpatients with different levels of anti-DNA antibodies. Anti-DNA antibody is not an important diagnostic and activity criterion for neuropsychiatric manifestations of SLE.