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In a study on 391 cases of BD¹ presented to the EULAR Congress of Rheumatology in 1987, we demonstrated that the following symptoms were seen more frequently in patients with positive pathergy phenomenon: oral aphthosis as the initial manifestation of the disease, and genital ulceration, pseudofolliculitis, and arthralgia as clinical symptoms. Ocular manifestations and ankylosing spondylitis, on the contrary, were seen less frequently in patients with positive pathergy test. Those data could suggest a relationship between the pathergy phenomenon and the above symptoms. However a statistical bias, especially due to the low number of patients, could also be suspected. It was therefore interesting to see, six years later and on a very large number of patients, if the same data could yet be found. In affirmative, the findings would more suggest a relationship between those symptoms than a statistical bias. A positive relationship between the pathergy phenomenon and other symptoms may then suggest an identical pathophysiological mechanism. The pathergy phenomenon, like other manifestations of the disease, follows the rule of attack and remission. It was therefore interesting to look for a possible relationship between the attacks of the pathergy phenomenon and the attacks of other symptoms. The first relationship would be more in favor of an identical terrain, while the second relationship would be more in favor of identical trigger factors.