Authors
Mastaneh Mohammadi, Farhad Shahram, Hormoz Shams, Massoomeh Akhlaghi, Farimah Ashofteh, Fereydoun Davatchi
Publication date
2017/9
Journal
International journal of rheumatic diseases
Volume
20
Issue
9
Pages
1269-1276
Description
Aim
To evaluate the efficacy of intravenous high‐dose pulses of methylprednisolone (IVPM) for treatment of ocular involvement in Behcet's disease (BD).
Method
In a double‐blind control study, we randomized BD patients with posterior uveitis (PU) and/or retinal vasculitis (RV) into two groups. They received either IVPM (1000 mg methylprednisolone) or placebo for 3 consecutive days. Both groups received combination therapy with IV cyclophosphamide, azathioprine and prednisolone for 6 months. Visual acuity (VA), Disease Activity Index (DAI) based on the inflammatory state of each section of each eye, total inflammatory (TIAI) and adjusted DAI (TADAI) for each patient were calculated. The comparisons were done by paired t‐ and Mann–Whitney U‐test.
Results
Seventeen patients in each group completed the treatment. The mean VA improved from 0.5 to 0.8 (P < 0.000001) for the study and from 0.6 to 0.7 …
Scholar articles
M Mohammadi, F Shahram, H Shams, M Akhlaghi… - International journal of rheumatic diseases, 2017