Authors
Gholamreza Daryabor, Mahdi Mahmoudi, Ahmadreza Jamshidi, Keramat Nourijelyani, Aliakbar Amirzargar, Nooshin Ahmadzadeh, Elham Farhadi, Mohammad Hossein Nicknam
Publication date
2014/3
Journal
European cytokine network
Volume
25
Pages
24-29
Publisher
John Libbey Eurotext
Description
Introduction
The result of recent genome-wide association studies revealed that, in addition to HLA-B27, a few non-HLA genes are associated with susceptibility to ankylosing spondylitis (AS) in Caucasian populations. According to these studies, IL-23R is one of the genes that is associated with AS. In this study, we evaluated five important single nucleotide polymorphisms (SNPs) of the IL-23R gene which confers susceptibility to AS, and its effects on the severity of the disease in HLA-B27 positive and negative patients and several subtypes of HLA-B27.
Materials and methods
The study population consisted of 294 AS patients and 352 age-, sex-, and ethnicity-matched healthy controls. All patients were examined by rheumatologists, and met modified,NewYork criteria for the disease. Five SNPs (rs1004819, rs11209032, rs1495965, rs11465804, and rs1004819 …
Scholar articles
G Daryabor, M Mahmoudi, A Jamshidi, K Nourijelyani… - European cytokine network, 2014