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The current study was planned to explore the therapeutic potency of M2000 (β‐D‐mannuronic acid), a novel designed non‐steroidal anti‐inflammatory drug (NSAID) in adjuvant‐induced arthritis model. Arthritis was induced in Lewis rats by a single intradermal injection (0.1 ml) of heat‐killed Mycobacterium tuberculosis (0.3 mg) in Freund's incomplete adjuvant into the right footpad. Fourteen days after injection of adjuvant, the contralateral left footpad volume was measured. The animals with paw volumes 0.37 ml greater than normal paws were then randomized into treatment groups. Orally and intraperitoneally administrations of test drugs (M2000, 40/mg/kg/day and indomethacin, 2/mg/kg/day) were started on day 15 post‐adjuvant injection and continued until final assessment on day 25. The left hind limb was removed for histological evaluation. The WEHI‐164 cell line was used for assaying tolerability and …