Authors
Omid Khalilzadeh, Mehdi Anvari, Alireza Esteghamati, Fatemeh Momen-Heravi, Armin Rashidi, Hoda Mojazi Amiri, Maryam Tahvildari, Mahdi Mahmoudi, Aliakbar Amirzargar
Publication date
2010/12/1
Journal
Ophthalmic genetics
Volume
31
Issue
4
Pages
215-220
Publisher
Taylor & Francis
Description
Background: Various polymorphisms occur in cytokine genes involved in inflammatory processes in Graves’ ophthalmopathy (GO). Anti-inflammatory cytokines such as transforming growth factor- β (TGF-β), interleukin-10 (IL-10) and interleukin-4 (IL-4) are among those believed to be involved in the disease process. In this study, we investigated the association between 8 polymorphisms within the mentioned cytokines and GO.
Methods: The following polymorphisms were studied in 50 patients with GO, 57 Graves’ patients without GO and 140 healthy individuals using polymerase chain reaction with sequence-specific primers: TGF-β (+869C/T, +915G/C), IL-10 (-1082A/G, -819C/T, -592C/A) and IL-4 (-1098T/G, -590T/C, -33C/T). A corrected p value less than 0.05 was considered statistically significant.
Results: The TGF-β +915C allele (Odds Ratio [OR] = 2.20) and CC genotype (OR = 7.50) as well as +869C …
Scholar articles
O Khalilzadeh, M Anvari, A Esteghamati… - Ophthalmic genetics, 2010