Authors
Omid Khalilzadeh, Mehdi Anvari, Alireza Esteghamati, Mahdi Mahmoudi, Maryam Tahvildari, Armin Rashidi, Farideh Khosravi, Aliakbar Amirzargar
Publication date
2009/8
Journal
Clinical & Experimental Ophthalmology
Volume
37
Issue
6
Pages
614-619
Publisher
Blackwell Publishing Asia
Description
Abstract
Purpose:  Interleukin‐1 (IL‐1) is known to have an important role in pathogenesis of Graves' ophthalmopathy (GO). Polymorphisms in IL‐1 gene have been associated with autoimmune reactions. This study aimed to investigate the association of GO with single‐nucleotide polymorphisms (SNPs) in the IL‐1 family (IL‐1α, IL‐1β, IL‐1 receptor [IL‐1R] and IL‐1 receptor antagonist [IL‐1RA]).
Methods:  A total of 57 patients of Graves' disease without GO, 50 patients with GO and 140 healthy controls were enrolled. Patients were recruited consecutively from the outpatient endocrine clinic of a large university general hospital. Cytokine typing was performed by the polymerase chain reaction with sequence‐specific primers assay. The allele and genotype frequencies of the following polymorphisms were determined: IL‐1α (−889C/T), IL‐1β (−511C/T), IL‐1β (+3962C/T), IL‐1R (Pst‐1 1970C/T) and IL‐1RA (Mspa‐1 …
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