Authors
Romina Dastmalchi, Ali Farazmand, Sina Noshad, Mohamad Mozafari, Mahdi Mahmoudi, Alireza Esteghamati, Aliakbar Amirzargar
Publication date
2014/8
Journal
Molecular biology reports
Volume
41
Pages
5367-5374
Publisher
Springer Netherlands
Description
Killer immunoglobulin-like receptors (KIR) play a pivotal role in commencement of both innate and adaptive immunity. Dysregulation of KIRs is associated with an increased risk of autoimmune disorders. This study was designed to assess whether polymorphisms in KIR gene family and their respective HLA class I ligands confer protection or susceptibly to Graves’ disease (GD). Eighty patients with confirmed GD (cases) and 176 healthy unrelated subjects (controls) were recruited. Using a polymerase chain reaction sequence-specific primer directed method (PCR-SSP), presence or absence of KIR genes and their HLA ligands were determined. No significant differences were observed between case and control groups regarding individual KIR gene frequencies (p > 0.05 in all cases). The frequency of group A haplotype (the most common KIR haplotype, encompassing 2DL1/2DL3/3DL1/2DS4/2DP1/3DP1 …
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