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The role of genetic factors in the pathogenesis of Graves’ disease (GD) is not clear. The purpose of this study was to investigate the association between single nucleotide polymorphisms in pro-inflammatory cytokine genes and GD in Iranian patients. A case–control hospital-based study was carried out on 107 GD patients and 140 healthy controls. Cytokine typing was performed by polymerase chain reaction with sequence-specific primers (PCR-SSP) assay. The allele and genotype frequencies of the following cytokine genes were determined: TNF-α (−308A/G, −238A/G), IL-2 (−330T/G, +166G/T), IL-6 (−174C/G, A/G nt565), IL-12 (−1188A/C), and IFN-γ (UTR 5644A/T). The following alleles and genotypes were significantly overrepresented in patients: TNF-α −308A allele (P < 0.01) and AA genotype (P < 0.05), IL-2 −330G allele (P < 0.01) and GG genotype (P < 0.01), IL-6 −174C allele (P < 0.01) and CC …