Authors
Esfandiar Azizi, Ahmad Massoud, Ali Akbar Amirzargar, Mahdi Mahmoudi, Narjes Soleimanifar, Nima Rezaei, Ahmad Reza Jamshidi, Behrouz Nikbin, Mohammad Hossein Nicknam
Publication date
2010/3
Journal
Journal of Clinical Immunology
Volume
30
Pages
268-271
Publisher
Springer US
Description
Introduction
Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is a costimulatory molecule expressed by activated T cells. This study was performed to investigate the allele and genotype frequencies of CTLA4 gene polymorphisms in Iranian patients with ankylosing spondylitis (AS).
Methods
One hundred and fifty-seven patients with AS and 103 controls were included in this study. Polymorphisms of CTLA4 gene at positions +49 (in exon 1), −318, and −1,147 (in the promoter region) were studied on the genomic DNA using PCR restriction fragment-length polymorphism method.
Results
The frequencies of the T allele at position −1147 in the patients with AS was significantly increased in comparison with the control group (11% vs. 5%, P = 0.004); whereas the frequencies of C allele at the same position were significantly …
Scholar articles
E Azizi, A Massoud, AA Amirzargar, M Mahmoudi… - Journal of Clinical Immunology, 2010