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Based on the documents in traditional medicine regarding the therapeutic effect of Sour orange flowers (Citrus aurantium L.) on the nervous system disorders, this experimental study was conducted to evaluate the pretreatment of Sour orange flowers extract in preventing or reducing depressive-like behaviors induced by systemic injection of lipopolysaccharide (LPS) in rats.

To perform this study, percolated extract of sour orange flowers was used. Each experimental group of animals was pretreated with the extract along with drinking water before the injection of LPS. The depressive-like behaviors induced by the injection of LPS consisted of the reduction in the preference for sucrose solutions, food consumption, body weight and inability to pleasure.

The LPS-injected rats that were chronically pretreated with the extract improved sucrose preference compared with control group, however …