Authors
Elham Barkhordari, Nima Rezaei, Bita Ansaripour, Pegah Larki, Maryam Alighardashi, Hamid Reza Ahmadi-Ashtiani, Mahdi Mahmoudi, Mohammad-Reza Keramati, Peiman Habibollahi, Mohammad Bashashati, Naser Ebrahimi-Daryani, Ali Akbar Amirzargar
Publication date
2010/1
Journal
Journal of clinical immunology
Volume
30
Pages
74-79
Publisher
Springer US
Description
Introduction
Irritable bowel syndrome (IBS) is a multifactorial functional gastrointestinal disorder, characterized by recurrent abdominal pain and altered bowel habits. Proinflammatory cytokines can play an important role in intestinal inflammation, while their production is under genetic control.
Methods
This study was performed in a group of patients with IBS to analyze the genotype frequencies of a number polymorphic genes coding for proinflammatory cytokine (interleukin-6 (IL), tumor necrosis factor-alpha (TNF-α), and IL-1 group). Using polymerase chain reaction with sequence-specific primers method, the cytokine genes were amplified, and alleles and genotypes of 71 patients with IBS were detected on gel electrophoresis, and the results were compared with healthy control subjects.
Results
Results of the analyzed …
Total citations
Scholar articles
E Barkhordari, N Rezaei, B Ansaripour, P Larki… - Journal of clinical immunology, 2010