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Background & objectives:. Despite extensive studies conducted on single nucleotide polymorphisms (SNPs) effects on different diseases, but the necessity of investigation into interaction of these SNPs together in diseases in particular genetic based diseases in one hand and existence of a large number of these variables and also weakness of classical statiscal models in including such variables in the other hand, underline the necessity of applying new statiscal method to determine these interaction effects. In this study we used logic feature selection approach to determine important SNP interactions associated with systemic lupus erythematosus. We use information of 11 SNPs located in the genes IL-1 cluster، IL-10، TNF-α، IL-4Rα for 376 subjects (188 control subjects and 188 case) to determine influential SNP interactions in patients affected with systemic lupus erythematosus disease …