Authors
Naheed Aryaeian, Mahsa Hadidi, Mahdi Mahmoudi, Marziyeh Asgari, Zohreh Sajadi Hezaveh, Sara Khorshidi Sadehi
Publication date
2021/2
Journal
Phytotherapy Research
Volume
35
Issue
2
Pages
1062-1068
Publisher
John Wiley & Sons, Ltd.
Description
Rheumatoid arthritis (RA) is an autoimmune disease associated with inflammation. In this trial, we aimed to investigate the Immunomodulatory effect of hydroalcoholic extract of black barberry on immune mediators in patients with active rheumatoid arthritis. In this randomized, double–blind, placebo‐controlled clinical trial, 80 women with active RA were randomly assigned into two groups of two capsules, each containing 1,000 mg black barberry extract (n = 40) or maltodextrin placebo (n = 40) daily for 12 weeks. Demographic indices, physical activity, dietary intake, and disease activity were investigated using suitable questionnaires. Concentration of cytokines IL‐2, IL‐4, IL‐10, and IL‐17 in blood sample were measured using PBMC method. Statistical analysis was performed using SPSS (version 22). At baseline, there were no differences between the two groups in terms of demographic indices, physical …
Total citations
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