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Results

The anti--enolase level among serum samples from RA patients was significantly higher than in healthy subjects (4.49±0.20 ng/ml vs. 0.76±0.12 ng/ml)(p< 0.001). There was a direct relation between-enolase quantity and (rheumatoid factor) RF and C-reactive protein (CRP) levels. The mean ESR value in positive and negative ACPA patients was 38.2±22.6 mm/h and 9.2±5.8 mm/h respectively (p< 0.0001). The mean DAS28-ESR was 3.3. The level of anti-MCV in the serum of RA patients (244.6±53.3 U/ml) was higher than in serum of the healthy group (148.73±71.8)(p< 0.0001). The level of anti-MCV in the SF of patients was 687.5±148.4 U/ml.

Conclusions

In conclusion, both autoantibodies against MCV and-enolase are two important markers that increase in serum and SF of RA patients and are specific for diagnosis of RA disease.