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Spondyloarthropathies(SpA), defined by inflammatory situations, are a category of rheumatic diseases with mainly involvement of the spine, enthuses, and peripheral joints. 1 Ankylosing spondylitis (AS), as the prototype of this category, is an autoimmune disease with a chronic inflammatory arthritis which is characterized by axial skeletal ankylosis, inflammation at the entheses, and arthritis of the peripheral limbs. 2 AS shows a strong association with Human Leucocyte Antigen (HLA)-B27 hereditary, and the misfolded HLA-B27 heavy chain homodimer in an animal model has supported the important role of this molecule in the pathogenesis of AS. 3 Toll-like receptors (TLRs) are categorized as type I integral membrane glycoproteins which play important roles in the innate immune system. In human, 11 members of TLR family have been identified. 4 There is an evidence demonstrating the role of TLR4 in the perforin production by helper T cells in ankylosing spondylitis. 5 Nevertheless, it has been demonstrated that the level of TLR4 protein on peripheral-blood leucocytes of AS patients and healthy individuals is