Authors
Mahdi Mahmoudi, Saeed Aslani
Publication date
2018/1/1
Source
The Epigenetics of Autoimmunity
Pages
387-402
Publisher
Academic Press
Description
Epigenetic modifications mediate environmental effects on gene expression and can influence the risk of diseases associated with genetic variants. Epigenetic evaluation provides a tool for understanding the mechanisms through which environmental and genetic factors collaborate to assign the disease risk. The spatial and temporal variance in the epigenetic profile is particularly relevant for developmental epidemiology and the study of aging, including the variable age of onset for many common diseases. However, personalized epigenetics has now been introduced as a promising strategy and can be used as an approach for the treatment of epigenetic-based diseases and others aspects of medicine. Epigenetic biomarkers and epigenomic signatures that are specific to each individual may be useful for the diagnosis of disorders and as prognostic tools for assessing the progression of diseases. This chapter will …
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