Authors
Sara Shahba, Reza Jafari Shakib, Ahmadreza Jamshidi, Mahdi Vojdanian, Maryam Akhtari, Saeed Aslani, Shiva Poursani, Iraj Nikokar, Mahdi Mahmoudi
Publication date
2019/5
Journal
Journal of cellular biochemistry
Volume
120
Issue
5
Pages
8359-8365
Description
Background
Copy number variation (CNV) of DNA segments has been considered as an important component of genetic variation, affecting the quality and quantity of gene expression. Bone morphogenic protein 8A (BMP8A) has been reported to function in bone formation. With respect to the bone and joint complications in ankylosing spondylitis (AS), this investigation aimed to study the role of BMP8A gene CNV in impressing the gene expression as well as the disease risk.
Methods
A total of 900 individuals, including 450 patients with AS and 450 healthy controls were enrolled. The copy numbers of BMP8A gene were detected by TaqMan real‐time polymerase chain reaction (PCR) method. BMP8A messenger RNA (mRNA) transcript level in peripheral blood mononuclear cells (PBMCs) was also measured by SYBR Green real‐time gene expression PCR method.
Results
No significant association of BMP8A …
Total citations
Scholar articles
S Shahba, R Jafari Shakib, A Jamshidi, M Vojdanian… - Journal of cellular biochemistry, 2019