Authors
Sahar Anaraki Mohammadi, Reza Mansouri, Abbas Shahi, Massoumeh Akhlaghi, Navid Dashti, Saeed Aslani, Mehrdad Mansouri, Shiva Poursani, Mahdi Mahmoudi
Publication date
2018/12/1
Journal
Meta Gene
Volume
18
Pages
149-152
Publisher
Elsevier
Description
Background
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease where it seems that different polymorphisms in cytokine genes are involved in the pathological process of this diseases. Interleukin 27 (IL-27) is a cytokine, which different studies have shown that it is similar to the double-edged sword, it means that it can play an anti- or pro-inflammatory role in chronic inflammatory diseases. The aim of this study is to identify the role of polymorphism in the IL27 gene and its possible association with susceptibility to RA.
Methods
Seven hundred patients with RA and 700 healthy individuals were genotyped for IL27 gene rs181206 polymorphism using PCR-RFLP method.
Result
Frequencies of the CT and CC + CT genotypes and the C allele were statistically higher in RA patients compared with the healthy control group (P = 0.012, P = 0.007 and P = 0.011 respectively). In RA patients, clinical …
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Scholar articles
SA Mohammadi, R Mansouri, A Shahi, M Akhlaghi… - Meta Gene, 2018