Authors
Majid Mahmoodi, Soheila Sobhani, Maassoumeh Akhlaghi, Shiva Poursani, Ahmadreza Jamshidi, Shayan Mostafaei, Saeed Aslani, Kouros Divsalar, Mahdi Mahmoudi
Publication date
2019/9/1
Journal
Meta Gene
Volume
21
Pages
100581
Publisher
Elsevier
Description
Background
Rheumatoid arthritis (RA) is an autoinflammatory disease, in which synovial cells in the joints produce a complex network of cytokines. Vascular endothelial growth factor (VEGF) has been reported to be overexpressed in RA patients. The aim of this study was to investigate the possible association of three single nucleotide polymorphisms (SNPs) of VEGFA gene with susceptibility to RA in Iranian population.
Methods
The study group was comprised of of 300 RA patients and 249 age, sex, and ethnicity matched healthy individuals. Three SNPs of rs2010963, rs833061, and rs3025039 in the VEGFA gene were genotyped in both case and control groups using TaqMan Real-time PCR allelic discrimination technique.
Results
Frequencies of neither the alleles nor genotypes of all three SNPs in VEGFA gene displayed significant differences between RA patients and healthy controls. Four haplotypes of TGC …
Total citations
Scholar articles
M Mahmoodi, S Sobhani, M Akhlaghi, S Poursani… - Meta Gene, 2019