Authors
S Abtahi, A Farazmand, M Mahmoudi, A Ashraf‐Ganjouei, A Javinani, B Nazari, H Kavosi, AA Amirzargar, AR Jamshidi, F Gharibdoost
Publication date
2015/12
Journal
International journal of immunogenetics
Volume
42
Issue
6
Pages
423-427
Description
Systemic Sclerosis (SSc) is a systemic autoimmune disorder, with ambiguous pathogenesis. Genetic and environmental factors were proved to be correlated with SSc aetiology. Single nucleotide polymorphisms (SNPs) in cytokine genes can alter the structure and function of the cytokines and consequently may increase the susceptibility to a specific disease. In this study, we investigated SNPs of the IL‐1 gene cluster in Iranian SSc patients. We obtained blood samples from 170 SSc patients and 213 healthy individuals. Cytokine genotyping results were obtained by polymerase chain reaction with sequence‐specific primers (PCR‐SSP). IL‐1A rs1800587, IL‐1B rs1143634 and IL‐1R1 rs2234650 were evaluated for SNP study. The frequency of the IL‐1B rs1143634 CT genotype was significantly lower in SSc patients compared to the controls (OR = 0.584; 95% CI = 0.385–0.886; P‐value = 0.023), so we propose …
Total citations
201620172018201920202021202220232024445224111