Authors
Soroush Ehsan, Aliakbar Amirzargar, Mir Saeed Yekaninejad, Mahdi Mahmoudi, Saeed Mehravar, Batoul Moradi, Shahriar Nafissi
Publication date
2015/12/15
Journal
Journal of the neurological sciences
Volume
359
Issue
1-2
Pages
335-342
Publisher
Elsevier
Description
Heterogenic pattern of HLA associations with myasthenia gravis (MG) among different ethnicities and also among different MG subgroups has been the subject of debate in large series of many studies. One hundred and sixty Iranian MG patients were investigated for HLA class II (DRB1, DQA1, DQB1) associations compared to two hundred healthy controls from the same ethnic population. DRB1*11 DQA1*0501 DQB1*0301 haplotype was found to be protective for total (ocular plus generalized) MG (Pc = 0.005, OR = 0.49) and generalized MG (Pc = 0.008, OR = 0.49). DRB1*04 DQA1*0301 DQB1*0302 haplotype (Pc = 0.03, OR = 2.25) was predisposing for anti-acetylcholine receptor (AChR) antibody-positive MG, while DRB1*16 DQA1*0102 DQB1*05 (Pc = 0.013, OR = 4.28) was predisposing for anti-muscle specific tyrosine kinase (MuSK) antibody-positive MG. There was also a trend of positive association for …
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