Authors
Fatemeh Ruhizadeh, Vahideh Imeni, Seyed Abdolhamid Angaji, Mahmoud Akbarian, Tahereh Faezi, Ahmadreza Jamshidi, Mahdi Mahmoudi
Publication date
2018/9/1
Journal
Gene Reports
Volume
12
Pages
175-178
Publisher
Elsevier
Description
Background
Systemic lupus erythematous (SLE) is an autoimmune disease characterized by autoantibody production, immune complex deposition, and involvement of the type I interferon (IFN) pathway. Interferon regulatory factor 5 (IRF5) is a transcription factor that regulates the transactivation of type I IFN system-related genes. The association of IRF5 gene single nucleotide polymorphisms (SNP) with SLE has been reported in different populations. The aim of this study was to investigate the association of IRF5 gene rs2004640 SNP with SLE susceptibility in Iranian population.
Methods and results
Genomic DNA was isolated from the peripheral blood leukocytes of 492 patients and 468 healthy individuals using the phenol-chloroform method. The TaqMan allelic discrimination Real-Time PCR method was applied to genotype rs2004640. The frequency of the rs2004640 T allele was significantly higher in SLE …
Total citations
Scholar articles
F Ruhizadeh, V Imeni, SA Angaji, M Akbarian, T Faezi… - Gene Reports, 2018