Authors
Hamid Dargahi, Mohammad Hossein Nicknam, Mahroo Mirahmadian, Mahdi Mahmoudi, Saeed Aslani, Maryam Sadrosadat, Robabeh Ghodssi-Ghassemabadi, Ali Akbar Amirzargar
Publication date
2019/3
Journal
Iranian Journal of Public Health
Volume
48
Issue
3
Pages
531
Publisher
Tehran University of Medical Sciences
Description
Background:
Endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and 2) are involved in blood pressure regulation and single nucleotide polymorphisms (SNPs) of these genes have been linked to preeclampsia. This study intended to assess the association of ERAP1 and 2 genes polymorphism with Iranian preeclamptic women.
Methods:
In this case-control study, 148 preeclamptic and 133 pregnant women were selected from the Kosar Hospital, Qazvin, Iran, during 2013–2015. In order to genotype the subjects for rs28096, rs30187, rs26653, rs3734016, rs34750 and rs2549782, rs17408150 for ERAP1 and 2 genes, respectively, Real-Time PCR allelic discrimination approach was exploited.
Results:
Neither allelic nor genotype frequencies of all seven polymorphisms were significantly different between two groups. Though, ACGACTT and GTCAGGA haplotypes were related with decreased (P= 0.0079, OR= 0 …
Total citations
Scholar articles
H Dargahi, MH Nicknam, M Mirahmadian, M Mahmoudi… - Iranian Journal of Public Health, 2019