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Vascular endothelial growth factor (VEGF) is a key mediator of angiogenesis and as a result acts in tumor invasion. In this study, we investigate the frequency of alleles, genotypes and haplotypes for three VEGF single nucleotide polymorphisms (SNP) in female breast cancer patients and healthy control group. We performed a case–control study including 214 female patients with pathologically proven breast cancer and 220 female age-matched healthy control subjects. We selected three VEGF candidate polymorphisms–634C/G (rs2010963),–460C/T (rs833061) and–1154A/G (rs1570360). Frequency of alleles and genotypes was determined by TaqMan real-time PCR allelic discrimination assay. The results have showed that there is not a significant difference in genotype and allele distributions of the VEGF–460T/C and VEGF–1154A/G between patients and controls. For–634C/G SNP, the frequency of–634G …