Authors
Hamidreza Ebrahimiyan, Ramazan Rezaei, Shayan Mostafaei, Saeed Aslani, George N Goulielmos, Ahmadreza Jamshidi, Mahdi Mahmoudi
Publication date
2018/6/1
Source
Meta Gene
Volume
16
Pages
241-247
Publisher
Elsevier
Description
Background
Signal Transducer and Activator of Transcription 4 (STAT4) is a transcription factor, which plays roles in the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus (SLE). Several genetic studies investigated the association of STAT4 gene polymorphisms and SLE risk in different populations, but their findings are incongruous. Here, we provided a comprehensive meta-analysis of all studies meeting the inclusion criteria to reveal the exact association between STAT4 gene polymorphisms and SLE risk.
Methods
We conducted a meta-analysis of all relevant studies published up to August 2017. We searched electronic databases, including Scopus, ISI Web of Science, ScienceDirect, and PubMed to find studies investigating the STAT4 polymorphisms and SLE in different populations. Pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were used to …
Scholar articles
H Ebrahimiyan, R Rezaei, S Mostafaei, S Aslani… - Meta Gene, 2018