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Cryogenically cooled low-noise amplifiers (LNAs) have had a profound impact on experimental science. For instance, these amplifiers allow us to communicate with distant spacecraft, probe the history and composition of the universe through radio astronomy, study basic phenomena through low-temperature physics research, and read out the state of quantum systems as required for quantum computing. These devices-which can achieve noise performance within an order of magnitude of the fundamental limits imposed by quantum mechanics-find use from low frequencies through several hundreds of gigahertz. Without cryogenic LNAs, whole branches of experimental science simply could not exist.