[HTML][HTML] Systematic substitutions at BLIP position 50 result in changes in binding specificity for class A β-lactamases
CJ Adamski, T Palzkill - BMC biochemistry, 2017 - Springer
Background The production of β-lactamases by bacteria is the most common mechanism of
resistance to the widely prescribed β-lactam antibiotics. β-lactamase inhibitory protein (BLIP) …
resistance to the widely prescribed β-lactam antibiotics. β-lactamase inhibitory protein (BLIP) …
[PDF][PDF] ß-Lactamase-Inhibitor Protein Binding Affinities: Detection of Hydrolysis of ß-Lactam Substrate by TEM-1 Enzyme and Inhibitor Binding Using The FlexStation® …
M Hanes, T Handel - moleculardevices.co.jp
Bacterial resistance to ß-lactam drugs through the production of class A ß-lactamase
enzymes is an increasing concern in the medical community. 1 ß-lactamase inhibitory …
enzymes is an increasing concern in the medical community. 1 ß-lactamase inhibitory …
[HTML][HTML] Dissecting the protein-protein interface between β-lactamase inhibitory protein and class A β-lactamases
Z Zhang, T Palzkill - Journal of Biological Chemistry, 2004 - ASBMB
β-Lactamase inhibitory protein (BLIP) binds and inhibits a diverse collection of class A β-
lactamases at a wide range of affinities. Alanine-scanning mutagenesis was previously …
lactamases at a wide range of affinities. Alanine-scanning mutagenesis was previously …
[HTML][HTML] Identification of the β-lactamase inhibitor protein-II (BLIP-II) interface residues essential for binding affinity and specificity for class A β-lactamases
NG Brown, DC Chow, KE Ruprecht, T Palzkill - Journal of Biological …, 2013 - ASBMB
The interactions between β-lactamase inhibitory proteins (BLIPs) and β-lactamases have
been used as model systems to understand the principles of affinity and specificity in protein …
been used as model systems to understand the principles of affinity and specificity in protein …
Role of β‐lactamase residues in a common interface for binding the structurally unrelated inhibitory proteins BLIP and BLIP‐II
BG Fryszczyn, CJ Adamski, NG Brown, K Rice… - Protein …, 2014 - Wiley Online Library
The β‐lactamase inhibitory proteins (BLIPs) are a model system for examining molecular
recognition in protein‐protein interactions. BLIP and BLIP‐II are structurally unrelated …
recognition in protein‐protein interactions. BLIP and BLIP‐II are structurally unrelated …
BLIP-II Employs Differential Hotspot Residues To Bind Structurally Similar Staphylococcus aureus PBP2a and Class A β-Lactamases
CJ Adamski, T Palzkill - Biochemistry, 2017 - ACS Publications
The interaction of β-lactamase inhibitory protein II (BLIP-II) with β-lactamases serves as a
model system to investigate the principles underlying protein–protein interactions. Previous …
model system to investigate the principles underlying protein–protein interactions. Previous …
[HTML][HTML] Engineering specificity from broad to narrow: Design of a BLIP variant that exclusively binds and detects KPC β-lactamase
DC Chow, K Rice, W Huang, RL Atmar… - ACS infectious …, 2016 - ncbi.nlm.nih.gov
The β-lactamase inhibitory protein (BLIP) binds and inhibits a wide range of class A β-
lactamases including the TEM-1 β-lactamase (K i= 0.5 nM), which is widely present in Gram …
lactamases including the TEM-1 β-lactamase (K i= 0.5 nM), which is widely present in Gram …
Identification of a β-lactamase inhibitory protein variant that is a potent inhibitor of Staphylococcus PC1 β-lactamase
J Yuan, DC Chow, W Huang, T Palzkill - Journal of molecular biology, 2011 - Elsevier
β-Lactamase inhibitory protein (BLIP) binds and inhibits a diverse collection of class A β-
lactamases. Widespread resistance to β-lactam antibiotics currently limits the treatment …
lactamases. Widespread resistance to β-lactam antibiotics currently limits the treatment …
[HTML][HTML] Analysis of the binding forces driving the tight interactions between β-lactamase inhibitory protein-II (BLIP-II) and class A β-lactamases
NG Brown, DC Chow, B Sankaran, P Zwart… - Journal of biological …, 2011 - ASBMB
β-Lactamases hydrolyze β-lactam antibiotics to provide drug resistance to bacteria. β-
Lactamase inhibitory protein-II (BLIP-II) is a potent proteinaceous inhibitor that exhibits low …
Lactamase inhibitory protein-II (BLIP-II) is a potent proteinaceous inhibitor that exhibits low …
Engineering specificity from broad to narrow: design of a β-lactamase inhibitory protein (BLIP) variant that exclusively binds and detects KPC β-lactamase
DC Chow, K Rice, W Huang, RL Atmar… - ACS Infectious …, 2016 - ACS Publications
The β-lactamase inhibitory protein (BLIP) binds and inhibits a wide range of class A β-
lactamases including the TEM-1 β-lactamase (K i= 0.5 nM), which is widely present in Gram …
lactamases including the TEM-1 β-lactamase (K i= 0.5 nM), which is widely present in Gram …
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