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Henry A. Lester
Henry A. Lester
Professor of Biology and Biological Engineering, Caltech
Verified email at caltech.edu
Title
Cited by
Year
Correspondence of fentanyl brain pharmacokinetics and behavior measured via engineering opioids biosensors and computational ethology
AK Muthusamy, M Rosenberg, CH Kim, AZ Wang, H Ebisu, TM Chin, ...
bioRxiv, 2024.03. 15.584894, 2024
2024
Antidepressants enter cells, organelles, and membranes
Z Blumenfeld, K Bera, E Castrén, HA Lester
Neuropsychopharmacology 49 (1), 246-261, 2024
12024
Interactive computational and experimental approaches improve the sensitivity of periplasmic binding protein-based nicotine biosensors for measurements in biofluids
N Haloi, S Huang, AL Nichols, EJ Fine, NJ Friesenhahn, CB Marotta, ...
Protein Engineering, Design and Selection 37, gzae003, 2024
2024
Human α6β4 nicotinic acetylcholine receptor: heterologous expression and agonist behavior provide insights into the immediate binding site
MC Maldifassi, HR Campello, T Gallagher, HA Lester, DA Dougherty
Molecular pharmacology 103 (6), 339-347, 2023
22023
β2 nAChR activation on VTA DA neurons is sufficient for nicotine reinforcement in rats
NB Walker, Y Yan, MA Tapia, BR Tucker, LN Thomas, BE George, ...
eneuro 10 (5), 2023
42023
Selective serotonin reuptake inhibitors within cells: temporal resolution in cytoplasm, endoplasmic reticulum, and membrane
AL Nichols, Z Blumenfeld, L Luebbert, HJ Knox, AK Muthusamy, ...
Journal of Neuroscience 43 (13), 2222-2241, 2023
82023
Correction: Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands
AL Nichols, Z Blumenfeld, C Fan, L Luebbert, AEM Blom, BN Cohen, ...
Elife 11, e85479, 2022
12022
Fluorescence Screens for Identifying Central Nervous System–Acting Drug–Biosensor Pairs for Subcellular and Supracellular Pharmacokinetics
ZG Beatty, AK Muthusamy, EK Unger, DA Dougherty, L Tian, LL Looger, ...
Bio-protocol 12 (22), e4551-e4551, 2022
52022
Characterization of binding site interactions and selectivity principles in the α3β4 nicotinic acetylcholine receptor
HJ Knox, H Rego Campello, HA Lester, T Gallagher, DA Dougherty
Journal of the American Chemical Society 144 (35), 16101-16117, 2022
102022
How many SARS-CoV-2 “viroporins” are really ion channels?
NL Harrison, GW Abbott, M Gentzsch, A Aleksandrov, A Moroni, G Thiel, ...
Communications Biology 5 (1), 859, 2022
112022
Engineered opioid biosensors
AK Muthusamy, HA Lester, L Looger, JS Marvin
US Patent App. 17/553,725, 2022
2022
Three mutations convert the selectivity of a protein sensor from nicotinic agonists to S-methadone for use in cells, organelles, and biofluids
AK Muthusamy, CH Kim, SC Virgil, HJ Knox, JS Marvin, AL Nichols, ...
Journal of the American Chemical Society 144 (19), 8480-8486, 2022
102022
Novel AlphasynucleinPAN in human Mesenchymal Stem Cells-derived neurons masks SNCA140 and creates dissociation of deleterious SNCA98 in astrocytoma …
AG Owoola, RK Okolicsanyi, LR Griffiths, LM Haupt
bioRxiv, 2022.02. 08.479501, 2022
2022
Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands
AL Nichols, Z Blumenfeld, C Fan, L Luebbert, AEM Blom, BN Cohen, ...
Elife 11, e74648, 2022
202022
Protein profiling in the habenula after chronic (–)‐menthol exposure in mice
MJ Mulcahy, SM Huard, JA Paulo, JH Wang, S McKinney, MJ Marks, ...
Journal of neurochemistry 158 (6), 1345-1358, 2021
32021
Regulation of epithelial sodium channel activity by SARS-CoV-1 and SARS-CoV-2 proteins
SN Grant, HA Lester
Biophysical journal 120 (14), 2805-2813, 2021
262021
Directed evolution of a selective and sensitive serotonin sensor via machine learning
EK Unger, JP Keller, M Altermatt, R Liang, A Matsui, C Dong, OJ Hon, ...
Cell 183 (7), 1986-2002. e26, 2020
1552020
Proteins for increased surface expression of the α6β4 nicotinic acetylcholine receptor: nothing but good news?
S Grant, HA Lester
The Journal of Clinical Investigation 130 (11), 5685-5687, 2020
22020
Antagonists pharmacologically chaperone opioid receptors
H Lester, S Grant
American Chemical Society SciMeetings 1 (2), 2020
2020
A fast genetically encoded fluorescent sensor for faithful in vivo acetylcholine detection in mice, fish, worms and flies
PM Borden, P Zhang, AV Shivange, JS Marvin, J Cichon, C Dan, ...
BioRxiv, 2020.02. 07.939504, 2020
822020
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