Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans SD Castillo, E Tzouanacou, M Zaw-Thin, IM Berenjeno, VER Parker, ... Science translational medicine 8 (332), 332ra43-332ra43, 2016 | 170 | 2016 |
PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia R Ola, A Dubrac, J Han, F Zhang, JS Fang, B Larrivée, M Lee, AA Urarte, ... Nature communications 7 (1), 13650, 2016 | 154 | 2016 |
Cell-cell junctions as sensors and transducers of mechanical forces A Angulo-Urarte, T van der Wal, S Huveneers Biochimica et Biophysica Acta (BBA)-Biomembranes 1862 (9), 183316, 2020 | 120 | 2020 |
PTEN mediates Notch-dependent stalk cell arrest in angiogenesis H Serra, I Chivite, A Angulo-Urarte, A Soler, JD Sutherland, ... Nature communications 6 (1), 1-13, 2015 | 109 | 2015 |
Sequential functions of CPEB1 and CPEB4 regulate pathologic expression of vascular endothelial growth factor and angiogenesis in chronic liver disease V Calderone, J Gallego, G Fernandez-Miranda, E Garcia-Pras, C Maillo, ... Gastroenterology 150 (4), 982-997. e30, 2016 | 72 | 2016 |
Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis A Soler, H Serra, W Pearce, A Angulo, J Guillermet-Guibert, LS Friedman, ... Journal of Experimental Medicine 210 (10), 1937-1945, 2013 | 70 | 2013 |
Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility A Angulo-Urarte, P Casado, SD Castillo, P Kobialka, MP Kotini, ... Nature communications 9 (1), 4826, 2018 | 56 | 2018 |
PI3K at the crossroads of tumor angiogenesis signaling pathways A Soler, A Angulo-Urarte, M Graupera Molecular & cellular oncology 2 (2), e975624, 2015 | 41 | 2015 |
Therapeutic benefit of selective inhibition of p110α PI3-kinase in pancreatic neuroendocrine tumors A Soler, AM Figueiredo, P Castel, L Martin, E Monelli, A Angulo-Urarte, ... Clinical Cancer Research 22 (23), 5805-5817, 2016 | 40 | 2016 |
Phosphoinositide 3-kinase–regulated pericyte maturation governs vascular remodeling AM Figueiredo, P Villacampa, R Diéguez-Hurtado, J José Lozano, ... Circulation 142 (7), 688-704, 2020 | 37 | 2020 |
A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis TS Malinova, A Angulo-Urarte, J Nüchel, M Tauber, MM van Der Stoel, ... Nature communications 12 (1), 2610, 2021 | 28 | 2021 |
The onset of PI3K‐related vascular malformations occurs during angiogenesis and is prevented by the AKT inhibitor miransertib P Kobialka, H Sabata, O Vilalta, L Gouveia, A Angulo‐Urarte, L Muixí, ... EMBO Molecular Medicine 14 (7), e15619, 2022 | 19 | 2022 |
When, where and which PIK3CA mutations are pathogenic in congenital disorders A Angulo-Urarte, M Graupera Nature Cardiovascular Research 1 (8), 700-714, 2022 | 7 | 2022 |
PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia. Nat Commun 7: 13650 R Ola, A Dubrac, J Han, F Zhang, JS Fang, B Larrivee, M Lee, AA Urarte, ... | 7 | 2016 |
Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans. Sci Transl Med 8: 332ra43 SD Castillo, E Tzouanacou, M Zaw-Thin, IM Berenjeno, VE Parker, ... | 6 | 2016 |
Low dose AKT inhibitor miransertib cures PI3K-related vascular malformations in preclinical models of human disease P Kobialka, H Sabata, O Vilalta, A Angulo-Urarte, L Muixí, J Zanoncello, ... bioRxiv, 2021.07. 16.452617, 2021 | 3 | 2021 |
PI3K-C2β limits mTORC1 signaling and angiogenic growth P Kobialka, J Llena, N Deleyto-Seldas, M Munar-Gelabert, JA Dengra, ... Science Signaling 16 (813), eadg1913, 2023 | | 2023 |
Asymmetric Endothelial Adherens Junctions in Angiogenesis A Angulo-Urarte, T Malinova, M Graupera, M Plomann, S Huveneers JOURNAL OF VASCULAR RESEARCH 56, 4-4, 2019 | | 2019 |
Regulation of actomyosin contractility by p110α P13-kinase in sprouting angiogenesis A Angulo Urarte Universitat de Barcelona, 2017 | | 2017 |
The p110alpha/PI3K controls endothelial cell rearrangements during angiogenesis by stimulating MLC2 dephosphorylation M Graupera, A Angulo-Urarte, P Kobialka, P Castel, PM Casado, ... Journal Of Vascular Research 54, 73-73, 2017 | | 2017 |