Copper-catalyzed trifluoromethylation of unactivated olefins AT Parsons, SL Buchwald Angewandte Chemie (International ed. in English) 50 (39), 9120, 2011 | 438 | 2011 |
Scope and mechanism for lewis acid-catalyzed cycloadditions of aldehydes and donor− acceptor cyclopropanes: Evidence for a stereospecific intimate ion pair pathway PD Pohlhaus, SD Sanders, AT Parsons, W Li, JS Johnson Journal of the American Chemical Society 130 (27), 8642-8650, 2008 | 392 | 2008 |
Catalytic enantioselective synthesis of tetrahydrofurans: a dynamic kinetic asymmetric [3+ 2] cycloaddition of racemic cyclopropanes and aldehydes AT Parsons, JS Johnson Journal of the American Chemical Society 131 (9), 3122-3123, 2009 | 331 | 2009 |
Room temperature aryl trifluoromethylation via copper-mediated oxidative cross-coupling TD Senecal, AT Parsons, SL Buchwald The Journal of Organic Chemistry 76 (4), 1174-1176, 2011 | 310 | 2011 |
Dynamic kinetic asymmetric synthesis of substituted pyrrolidines from racemic cyclopropanes and aldimines: reaction development and mechanistic insights AT Parsons, AG Smith, AJ Neel, JS Johnson Journal of the American Chemical Society 132 (28), 9688-9692, 2010 | 246 | 2010 |
Iron (II)-catalyzed trifluoromethylation of potassium vinyltrifluoroborates AT Parsons, TD Senecal, SL Buchwald Angewandte Chemie (International ed. in English) 51 (12), 2947, 2012 | 232 | 2012 |
Complexity-Building Annulations of Strained Cycloalkanes and C O π Bonds MJ Campbell, JS Johnson, AT Parsons, PD Pohlhaus, SD Sanders The Journal of Organic Chemistry 75 (19), 6317-6325, 2010 | 194 | 2010 |
Diastereoselective synthesis of tetrahydrofurans via palladium (0)-catalyzed [3+ 2] cycloaddition of vinylcyclopropanes and aldehydes AT Parsons, MJ Campbell, JS Johnson Organic Letters 10 (12), 2541-2544, 2008 | 159 | 2008 |
Formal [4+ 2] Cycloaddition of Donor− Acceptor Cyclobutanes and Aldehydes: Stereoselective Access to Substituted Tetrahydropyrans AT Parsons, JS Johnson Journal of the American Chemical Society 131 (40), 14202-14203, 2009 | 122 | 2009 |
Oxopyrido[2,3-d]pyrimidines as Covalent L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors RP Wurz, LH Pettus, K Ashton, J Brown, JJ Chen, B Herberich, FT Hong, ... ACS Medicinal Chemistry Letters 6 (9), 987-992, 2015 | 30 | 2015 |
A radical approach to diversity AT Parsons, SL Buchwald Nature 480 (7376), 184-185, 2011 | 29 | 2011 |
Continuous process improvement in the manufacture of Carfilzomib, part 2: an improved process for synthesis of the Epoxyketone warhead MG Beaver, X Shi, J Riedel, P Patel, A Zeng, MT Corbett, JA Robinson, ... Organic Process Research & Development 24 (4), 490-499, 2020 | 22 | 2020 |
Addressing atropisomerism in the development of sotorasib, a covalent inhibitor of KRAS G12C: structural, analytical, and synthetic considerations BA Lanman, AT Parsons, SG Zech Accounts of Chemical Research 55 (20), 2892-2903, 2022 | 21 | 2022 |
A virtual Plant for Integrated Continuous Manufacturing of a Carfilzomib drug substance intermediate, part 2: Enone synthesis via a Barbier-type Grignard process E Içten, AJ Maloney, MG Beaver, X Zhu, DE Shen, JA Robinson, ... Organic Process Research & Development 24 (10), 1876-1890, 2020 | 21 | 2020 |
Synthesis of perfluoroalkyl-substituted oxindoles through organophotoredox-catalyzed perfluoroalkylation of N-arylacrylamides with perfluoroalkyl iodides Z Yang, A Tang Synlett 30 (09), 1061-1066, 2019 | 20 | 2019 |
Enantioselective synthesis of a γ-secretase modulator via vinylogous dynamic kinetic resolution NA Strotman, A Ramirez, EM Simmons, O Soltani, AT Parsons, Y Fan, ... The Journal of Organic Chemistry 83 (18), 11133-11144, 2018 | 18 | 2018 |
Axial chirality in the sotorasib drug substance, Part 1: Development of a classical resolution to prepare an atropisomerically pure sotorasib intermediate AT Parsons, S Caille, MA Caporini, DJ Griffin, MA Lovette, W Powazinik IV, ... Organic Process Research & Development 26 (9), 2629-2635, 2022 | 16 | 2022 |
Synthesis of key intermediate of KRAS G12C inhibitor compound AT Parsons, BM Cochran, W POWAZINIK IV, MA Caporini US Patent 11,299,491, 2022 | 16 | 2022 |
Palladium (0)-Catalyzed Diastereoselective (3+ 2) Cycloadditions of Vinylcyclopropanes with Sulfonyl-Activated Imines J Ling, M Laugeois, V Ratovelomanana-Vidal, MR Vitale Synlett 29 (17), 2288-2292, 2018 | 16 | 2018 |
Development of a Commercial Manufacturing Process for Sotorasib, a First-in-Class KRASG12C Inhibitor L Zhang, DJ Griffin, MG Beaver, LE Blue, CJ Borths, DB Brown, S Caille, ... Organic Process Research & Development 26 (11), 3115-3125, 2022 | 15 | 2022 |