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Andrew T Parsons
Andrew T Parsons
Verified email at amgen.com
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Year
Copper-catalyzed trifluoromethylation of unactivated olefins
AT Parsons, SL Buchwald
Angewandte Chemie (International ed. in English) 50 (39), 9120, 2011
4382011
Scope and mechanism for lewis acid-catalyzed cycloadditions of aldehydes and donor− acceptor cyclopropanes: Evidence for a stereospecific intimate ion pair pathway
PD Pohlhaus, SD Sanders, AT Parsons, W Li, JS Johnson
Journal of the American Chemical Society 130 (27), 8642-8650, 2008
3922008
Catalytic enantioselective synthesis of tetrahydrofurans: a dynamic kinetic asymmetric [3+ 2] cycloaddition of racemic cyclopropanes and aldehydes
AT Parsons, JS Johnson
Journal of the American Chemical Society 131 (9), 3122-3123, 2009
3312009
Room temperature aryl trifluoromethylation via copper-mediated oxidative cross-coupling
TD Senecal, AT Parsons, SL Buchwald
The Journal of Organic Chemistry 76 (4), 1174-1176, 2011
3102011
Dynamic kinetic asymmetric synthesis of substituted pyrrolidines from racemic cyclopropanes and aldimines: reaction development and mechanistic insights
AT Parsons, AG Smith, AJ Neel, JS Johnson
Journal of the American Chemical Society 132 (28), 9688-9692, 2010
2462010
Iron (II)-catalyzed trifluoromethylation of potassium vinyltrifluoroborates
AT Parsons, TD Senecal, SL Buchwald
Angewandte Chemie (International ed. in English) 51 (12), 2947, 2012
2322012
Complexity-Building Annulations of Strained Cycloalkanes and C O π Bonds
MJ Campbell, JS Johnson, AT Parsons, PD Pohlhaus, SD Sanders
The Journal of Organic Chemistry 75 (19), 6317-6325, 2010
1942010
Diastereoselective synthesis of tetrahydrofurans via palladium (0)-catalyzed [3+ 2] cycloaddition of vinylcyclopropanes and aldehydes
AT Parsons, MJ Campbell, JS Johnson
Organic Letters 10 (12), 2541-2544, 2008
1592008
Formal [4+ 2] Cycloaddition of Donor− Acceptor Cyclobutanes and Aldehydes: Stereoselective Access to Substituted Tetrahydropyrans
AT Parsons, JS Johnson
Journal of the American Chemical Society 131 (40), 14202-14203, 2009
1222009
Oxopyrido[2,3-d]pyrimidines as Covalent L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors
RP Wurz, LH Pettus, K Ashton, J Brown, JJ Chen, B Herberich, FT Hong, ...
ACS Medicinal Chemistry Letters 6 (9), 987-992, 2015
302015
A radical approach to diversity
AT Parsons, SL Buchwald
Nature 480 (7376), 184-185, 2011
292011
Continuous process improvement in the manufacture of Carfilzomib, part 2: an improved process for synthesis of the Epoxyketone warhead
MG Beaver, X Shi, J Riedel, P Patel, A Zeng, MT Corbett, JA Robinson, ...
Organic Process Research & Development 24 (4), 490-499, 2020
222020
Addressing atropisomerism in the development of sotorasib, a covalent inhibitor of KRAS G12C: structural, analytical, and synthetic considerations
BA Lanman, AT Parsons, SG Zech
Accounts of Chemical Research 55 (20), 2892-2903, 2022
212022
A virtual Plant for Integrated Continuous Manufacturing of a Carfilzomib drug substance intermediate, part 2: Enone synthesis via a Barbier-type Grignard process
E Içten, AJ Maloney, MG Beaver, X Zhu, DE Shen, JA Robinson, ...
Organic Process Research & Development 24 (10), 1876-1890, 2020
212020
Synthesis of perfluoroalkyl-substituted oxindoles through organophotoredox-catalyzed perfluoroalkylation of N-arylacrylamides with perfluoroalkyl iodides
Z Yang, A Tang
Synlett 30 (09), 1061-1066, 2019
202019
Enantioselective synthesis of a γ-secretase modulator via vinylogous dynamic kinetic resolution
NA Strotman, A Ramirez, EM Simmons, O Soltani, AT Parsons, Y Fan, ...
The Journal of Organic Chemistry 83 (18), 11133-11144, 2018
182018
Axial chirality in the sotorasib drug substance, Part 1: Development of a classical resolution to prepare an atropisomerically pure sotorasib intermediate
AT Parsons, S Caille, MA Caporini, DJ Griffin, MA Lovette, W Powazinik IV, ...
Organic Process Research & Development 26 (9), 2629-2635, 2022
162022
Synthesis of key intermediate of KRAS G12C inhibitor compound
AT Parsons, BM Cochran, W POWAZINIK IV, MA Caporini
US Patent 11,299,491, 2022
162022
Palladium (0)-Catalyzed Diastereoselective (3+ 2) Cycloadditions of Vinylcyclopropanes with Sulfonyl-Activated Imines
J Ling, M Laugeois, V Ratovelomanana-Vidal, MR Vitale
Synlett 29 (17), 2288-2292, 2018
162018
Development of a Commercial Manufacturing Process for Sotorasib, a First-in-Class KRASG12C Inhibitor
L Zhang, DJ Griffin, MG Beaver, LE Blue, CJ Borths, DB Brown, S Caille, ...
Organic Process Research & Development 26 (11), 3115-3125, 2022
152022
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