| Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus L Whitesell, N Robbins, DS Huang, CA McLellan, T Shekhar-Guturja, ... Nature Communications 10 (1), 402, 2019 | 98 | 2019 |
| eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma K Chan, F Robert, C Oertlin, D Kapeller-Libermann, D Avizonis, ... Nature communications 10 (1), 1-16, 2019 | 80 | 2019 |
| Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma S Manier, D Huynh, YJ Shen, J Zhou, T Yusufzai, KZ Salem, RY Ebright, ... Science translational medicine 9 (389), eaal2668, 2017 | 69 | 2017 |
| Nanoparticle-mediated intervalence transfer W Chen, S Chen, F Ding, H Wang, LE Brown, JP Konopelski Journal of the American Chemical Society 130 (36), 12156-12162, 2008 | 66 | 2008 |
| Amidino-rocaglates: a potent class of eIF4A inhibitors J Chu, W Zhang, R Cencic, WG Devine, D Beglov, T Henkel, LE Brown, ... Cell chemical biology 26 (11), 1586-1593. e3, 2019 | 63 | 2019 |
| Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F J Chu, W Zhang, R Cencic, PBF O’Connor, F Robert, WG Devine, ... Cell Reports 30 (8), 2481-2488. e5, 2020 | 60 | 2020 |
| Janus nanoparticles: reaction dynamics and NOESY characterization S Pradhan, LE Brown, JP Konopelski, S Chen Journal of Nanoparticle Research 11 (8), 1895-1903, 2009 | 60 | 2009 |
| Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer O Levi-Galibov, H Lavon, R Wassermann-Dozorets, M Pevsner-Fischer, ... Nature communications 11 (1), 1-19, 2020 | 59 | 2020 |
| Design and synthesis of fungal-selective resorcylate aminopyrazole Hsp90 inhibitors D Huang, E LeBlanc, T Shekhar-Guturja, N Robbins, D Krysan, JC Pizarro, ... Journal of Medicinal Chemistry, 2019 | 58 | 2019 |
| A novel class of small molecule compounds that inhibit hepatitis C virus infection by targeting the prohibitin-CRaf pathway S Liu, W Wang, LE Brown, C Qiu, N Lajkiewicz, T Zhao, J Zhou, ... EBioMedicine 2 (11), 1600-1606, 2015 | 57 | 2015 |
| Welwistatin support studies: Expansion and limitation of aryllead (IV) coupling reactions J Xia, LE Brown, JP Konopelski The Journal of organic chemistry 72 (18), 6885-6890, 2007 | 55 | 2007 |
| An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris KR Iyer, K Camara, M Daniel-Ivad, R Trilles, SM Pimentel-Elardo, ... Nature Communications 11 (1), 1-17, 2020 | 47 | 2020 |
| Discovery of new antimalarial chemotypes through chemical methodology and library development LE Brown, KCC Cheng, WG Wei, P Yuan, P Dai, R Trilles, F Ni, J Yuan, ... Proceedings of the National Academy of Sciences 108 (17), 6775-6780, 2011 | 47 | 2011 |
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space SE Kearney, G Zahoránszky-Kőhalmi, KR Brimacombe, MJ Henderson, ... ACS Central Science, 2018 | 37 | 2018 |
| Turning the Corner: Recent Advances in the Synthesis of the Welwitindolinones LE Brown, JP Konopelski Organic Preparations and Procedures International 40 (5), 411-445, 2008 | 36 | 2008 |
| Translation inhibition by rocaglates activates a species-specific cell death program in the emerging fungal pathogen Candida auris KR Iyer, L Whitesell, JA Porco Jr, T Henkel, LE Brown, N Robbins, ... MBio 11 (2), e03329-19, 2020 | 34 | 2020 |
| Rocaglates as dual-targeting agents for experimental cerebral malaria D Langlais, R Cencic, N Moradin, JM Kennedy, K Ayi, LE Brown, ... Proceedings of the National Academy of Sciences 115 (10), E2366-E2375, 2018 | 34 | 2018 |
| Progress toward the total synthesis of psymberin/irciniastatin A LE Brown, YR Landaverry, JR Davies, KA Milinkevich, S Ast, JS Carlson, ... The Journal of organic chemistry 74 (15), 5405-5410, 2009 | 34 | 2009 |
| Total Syntheses of the Isomeric Aglain Natural Products Foveoglin A and Perviridisin B via Selective ESIPT Photocycloaddition J Porco, W Wang, A Clay, R Krishnan, NJ Lajkiewicz, LE Brown, ... Angewandte Chemie International Edition, 0 | 33* | |
| Intercepted retro-Nazarov reaction: syntheses of amidino-rocaglate derivatives and their biological evaluation as eIF4A inhibitors W Zhang, J Chu, AM Cyr, H Yueh, LE Brown, TT Wang, J Pelletier, ... Journal of the American Chemical Society 141 (32), 12891-12900, 2019 | 31 | 2019 |
