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George Sflomos, M.Sc., Ph.D.
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Patient-derived xenograft (PDX) models in basic and translational breast cancer research
LE Dobrolecki, SD Airhart, DG Alferez, S Aparicio, F Behbod, ...
Cancer and Metastasis Reviews 35, 547-573, 2016
2522016
Progesterone/RANKL is a major regulatory axis in the human breast
T Tanos, G Sflomos, PC Echeverria, A Ayyanan, M Gutierrez, JF Delaloye, ...
Science translational medicine 5 (182), 182ra55-182ra55, 2013
2122013
A preclinical model for ERα-positive breast cancer points to the epithelial microenvironment as determinant of luminal phenotype and hormone response
G Sflomos, V Dormoy, T Metsalu, R Jeitziner, L Battista, V Scabia, ...
Cancer cell 29 (3), 407-422, 2016
1982016
Characterization of circulating breast cancer cells with tumorigenic and metastatic capacity
EMBO Mol Med . 11908, 2020
972020
Estrogen receptor positive breast cancers have patient specific hormone sensitivities and rely on progesterone receptor
V Scabia, A Ayyanan, F De Martino, A Agnoletto, L Battista, C Laszlo, ...
Nature Communications 13 (1), 3127, 2022
642022
The histone chaperone SET/TAF-Iβ interacts functionally with the CREB-binding protein
Z Karetsou, G Martic, G Sflomos, T Papamarcaki
Biochemical and Biophysical Research Communications 335 (2), 322-327, 2005
462005
The challenges of modeling hormone receptor-positive breast cancer in mice
BC Özdemir, G Sflomos, C Brisken
Endocrine-related cancer 25 (5), R319-R330, 2018
422018
SARA and RNF11 interact with each other and ESCRT-0 core proteins and regulate degradative EGFR trafficking
E Kostaras, G Sflomos, NM Pedersen, H Stenmark, T Fotsis, C Murphy
Oncogene 32 (44), 5220-5232, 2013
362013
ERBIN is a new SARA-interacting protein: competition between SARA and SMAD2 and SMAD3 for binding to ERBIN
G Sflomos, E Kostaras, E Panopoulou, N Pappas, A Kyrkou, AS Politou, ...
Journal of cell science 124 (19), 3209-3222, 2011
362011
Oestrogen receptor α AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium
S Cagnet, D Ataca, G Sflomos, P Aouad, S Schuepbach-Mallepell, ...
Nature communications 9 (1), 4723, 2018
352018
Intraductal patient‐derived xenografts of estrogen receptor α‐positive breast cancer recapitulate the histopathological spectrum and metastatic potential of human lesions
M Fiche, V Scabia, P Aouad, L Battista, A Treboux, A Stravodimou, ...
The Journal of pathology 247 (3), 287-292, 2019
342019
Intraductal xenografts show lobular carcinoma cells rely on their own extracellular matrix and LOXL1
G Sflomos, L Battista, P Aouad, F De Martino, V Scabia, A Stravodimou, ...
EMBO Molecular Medicine 13 (3), e13180, 2021
322021
Epithelial-mesenchymal plasticity determines estrogen receptor positive breast cancer dormancy and epithelial reconversion drives recurrence
P Aouad, Y Zhang, F De Martino, C Stibolt, S Ali, G Ambrosini, SA Mani, ...
Nature communications 13 (1), 4975, 2022
24*2022
Atlas of lobular breast cancer models: challenges and strategic directions
G Sflomos, K Schipper, T Koorman, A Fitzpatrick, S Oesterreich, AV Lee, ...
Cancers 13 (21), 5396, 2021
232021
Contraceptive progestins with androgenic properties stimulate breast epithelial cell proliferation
M Shamseddin, F De Martino, C Constantin, V Scabia, AS Lancelot, ...
EMBO Molecular Medicine 13 (7), e14314, 2021
232021
A novel culture method that sustains ERα signaling in human breast cancer tissue microstructures
AL Cartaxo, MF Estrada, G Domenici, R Roque, F Silva, EJ Gualda, ...
Journal of Experimental & Clinical Cancer Research 39, 1-14, 2020
202020
An ex vivo model to study hormone action in the human breast
G Sflomos, M Shamseddin, C Brisken
JoVE (Journal of Visualized Experiments), e52436, 2015
82015
A new Achilles Heel in breast cancer?
G Sflomos, C Brisken
Oncotarget 4 (8), 1126, 2013
82013
Breast Cancer Microenvironment and the Metastatic Process
G Sflomos, C Brisken
Breast Cancer, pp.39-48, 2017
42017
Acetyl-CoA carboxylase 1 controls a lipid droplet–peroxisome axis and is a vulnerability of endocrine-resistant ER+ breast cancer
M Bacci, N Lorito, A Smiriglia, A Subbiani, F Bonechi, G Comito, ...
Science Translational Medicine 16 (736), eadf9874, 2024
12024
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