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David Ruddy
David Ruddy
Senior Scientific Technical Leader, Novartis
Verified email at novartis.com
Title
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Cited by
Year
A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis
JN Feder, A Gnirke, W Thomas, Z Tsuchihashi, DA Ruddy, A Basava, ...
Nature genetics 13 (4), 399-408, 1996
46621996
High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response
H Gao, JM Korn, S Ferretti, JE Monahan, Y Wang, M Singh, C Zhang, ...
Nature medicine 21 (11), 1318-1325, 2015
13132015
aph-1 and pen-2 are required for Notch pathway signaling, γ-secretase cleavage of βAPP, and presenilin protein accumulation
R Francis, G McGrath, J Zhang, DA Ruddy, M Sym, J Apfeld, M Nicoll, ...
Developmental cell 3 (1), 85-97, 2002
11792002
Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition
AN Hata, MJ Niederst, HL Archibald, M Gomez-Caraballo, FM Siddiqui, ...
Nature medicine 22 (3), 262-269, 2016
9092016
HFE gene knockout produces mouse model of hereditary hemochromatosis
XY Zhou, S Tomatsu, RE Fleming, S Parkkila, A Waheed, J Jiang, Y Fei, ...
Proceedings of the National Academy of Sciences 95 (5), 2492-2497, 1998
6191998
An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (enzalutamide)
M Korpal, JM Korn, X Gao, DP Rakiec, DA Ruddy, S Doshi, J Yuan, ...
Cancer discovery 3 (9), 1030-1043, 2013
6002013
Project DRIVE: a compendium of cancer dependencies and synthetic lethal relationships uncovered by large-scale, deep RNAi screening
ER McDonald, A De Weck, MR Schlabach, E Billy, KJ Mavrakis, ...
Cell 170 (3), 577-592. e10, 2017
5972017
Studying clonal dynamics in response to cancer therapy using high-complexity barcoding
HC Bhang, DA Ruddy, V Krishnamurthy Radhakrishna, JX Caushi, ...
Nature medicine 21 (5), 440-448, 2015
5192015
Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5
KJ Mavrakis, ER McDonald III, MR Schlabach, E Billy, GR Hoffman, ...
Science 351 (6278), 1208-1213, 2016
4262016
CRISPR screens provide a comprehensive assessment of cancer vulnerabilities but generate false-positive hits for highly amplified genomic regions
DM Munoz, PJ Cassiani, L Li, E Billy, JM Korn, MD Jones, J Golji, ...
Cancer discovery 6 (8), 900-913, 2016
3772016
Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss
H Liu, J Golji, LK Brodeur, FS Chung, JT Chen, RS deBeaumont, ...
Nature medicine 25 (1), 95-102, 2019
2512019
SHP2 inhibition restores sensitivity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors
L Dardaei, HQ Wang, M Singh, P Fordjour, KX Shaw, S Yoda, G Kerr, ...
Nature medicine 24 (4), 512-517, 2018
1852018
Targeting FGFR overcomes EMT-mediated resistance in EGFR mutant non-small cell lung cancer
S Raoof, IJ Mulford, H Frisco-Cabanos, V Nangia, D Timonina, E Labrot, ...
Oncogene 38 (37), 6399-6413, 2019
1782019
KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer
EB Krall, B Wang, DM Munoz, N Ilic, S Raghavan, MJ Niederst, K Yu, ...
Elife 6, e18970, 2017
1502017
Development of secondary mutations in wild-type and mutant EZH2 alleles cooperates to confer resistance to EZH2 inhibitors
V Gibaja, F Shen, J Harari, J Korn, D Ruddy, V Saenz-Vash, H Zhai, ...
Oncogene 35 (5), 558-566, 2016
1472016
A chemical genetics approach for the functional assessment of novel cancer genes
Q Zhou, A Derti, D Ruddy, D Rakiec, I Kao, M Lira, V Gibaja, HM Chan, ...
Cancer research 75 (10), 1949-1958, 2015
1302015
A drug resistance screen using a selective MET inhibitor reveals a spectrum of mutations that partially overlap with activating mutations found in cancer patients
R Tiedt, E Degenkolbe, P Furet, BA Appleton, S Wagner, J Schoepfer, ...
Cancer research 71 (15), 5255-5264, 2011
1262011
Single nucleotide polymorphism markers for genetic mapping in Drosophila melanogaster
RA Hoskins, AC Phan, M Naeemuddin, FA Mapa, DA Ruddy, JJ Ryan, ...
Genome research 11 (6), 1100-1113, 2001
1252001
TGFβ-blockade uncovers stromal plasticity in tumors by revealing the existence of a subset of interferon-licensed fibroblasts
AL Grauel, B Nguyen, D Ruddy, T Laszewski, S Schwartz, J Chang, ...
Nature communications 11 (1), 6315, 2020
1202020
Loss of tuberous sclerosis complex 2 (TSC2) is frequent in hepatocellular carcinoma and predicts response to mTORC1 inhibitor everolimus
H Huynh, HX Hao, SL Chan, D Chen, R Ong, KC Soo, P Pochanard, ...
Molecular cancer therapeutics 14 (5), 1224-1235, 2015
1162015
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