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Yaw Sing Tan
Yaw Sing Tan
Bioinformatics Institute
Verified email at bii.a-star.edu.sg
Title
Cited by
Cited by
Year
A strategy for the diversity-oriented synthesis of macrocyclic scaffolds using multidimensional coupling
HSG Beckmann, F Nie, CE Hagerman, H Johansson, YS Tan, D Wilcke, ...
Nature chemistry 5 (10), 861-867, 2013
1252013
Stapled peptide design: principles and roles of computation
YS Tan, DP Lane, CS Verma
Drug Discovery Today 21 (10), 1642-1653, 2016
1242016
Double strain‐promoted macrocyclization for the rapid selection of cell‐active stapled peptides
YH Lau, Y Wu, M Rossmann, BX Tan, P de Andrade, YS Tan, C Verma, ...
Angewandte Chemie International Edition 54 (51), 15410-15413, 2015
1172015
Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2
M Janeček, M Rossmann, P Sharma, A Emery, DJ Huggins, SR Stockwell, ...
Scientific Reports 6 (1), 28528, 2016
912016
Diversity-oriented synthesis as a tool for identifying new modulators of mitosis
BM Ibbeson, L Laraia, E Alza, CJ O'Connor, YS Tan, HML Davies, ...
Nature communications 5 (1), 3155, 2014
912014
Using ligand-mapping simulations to design a ligand selectively targeting a cryptic surface pocket of polo-like kinase 1
YS Tan, P Śledź, S Lang, CJ Stubbs, DR Spring, C Abell, RB Best
Angewandte Chemie (International ed. in English) 51 (40), 10078, 2012
882012
Macrocyclized extended peptides: inhibiting the substrate-recognition domain of tankyrase
W Xu, YH Lau, G Fischer, YS Tan, A Chattopadhyay, M de la Roche, ...
Journal of the American Chemical Society 139 (6), 2245-2256, 2017
662017
Macrocyclic α helical peptide therapeutic modality: A perspective of learnings and challenges
TK Sawyer, AW Partridge, HYK Kaan, YC Juang, S Lim, C Johannes, ...
Bioorganic & Medicinal Chemistry 26 (10), 2807-2815, 2018
612018
Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide
BH Liu, C Jobichen, CSB Chia, THM Chan, JP Tang, TXY Chung, J Li, ...
Proceedings of the National Academy of Sciences 115 (30), E7119-E7128, 2018
552018
Development of Cell‐Permeable, Non‐Helical Constrained Peptides to Target a Key Protein–Protein Interaction in Ovarian Cancer
MM Wiedmann, YS Tan, Y Wu, S Aibara, W Xu, HF Sore, CS Verma, ...
Angewandte Chemie International Edition 56 (2), 524-529, 2017
542017
Synthesis and biological profiling of tellimagrandin I and analogues reveals that the medium ring can significantly modulate biological activity
S Zheng, L Laraia, CJ O'Connor, D Sorrell, YS Tan, Z Xu, ...
Organic & Biomolecular Chemistry 10 (13), 2590-2593, 2012
512012
Incorporation of putative helix-breaking amino acids in the design of novel stapled peptides: Exploring biophysical and cellular permeability properties
AW Partridge, HYK Kaan, YC Juang, A Sadruddin, S Lim, CJ Brown, S Ng, ...
Molecules 24 (12), 2292, 2019
502019
The p53–Mdm2 interaction and the E3 ligase activity of Mdm2/Mdm4 are conserved from lampreys to humans
CR Coffill, AP Lee, JW Siau, SM Chee, TL Joseph, YS Tan, ...
Genes & development 30 (3), 281-292, 2016
462016
Benzene probes in molecular dynamics simulations reveal novel binding sites for ligand design
YS Tan, J Reeks, CJ Brown, D Thean, FJ Ferrer Gago, TY Yuen, ETL Goh, ...
The Journal of Physical Chemistry Letters 7 (17), 3452-3457, 2016
452016
Stapled peptides as a new technology to investigate protein–protein interactions in human platelets
J Iegre, NS Ahmed, JS Gaynord, Y Wu, KM Herlihy, YS Tan, ...
Chemical Science 9 (20), 4638-4643, 2018
432018
Decreased GLUT2 and glucose uptake contribute to insulin secretion defects in MODY3/HNF1A hiPSC-derived mutant β cells
BSJ Low, CS Lim, SSL Ding, YS Tan, NHJ Ng, VG Krishnan, SF Ang, ...
Nature communications 12 (1), 3133, 2021
412021
Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell
A Chattopadhyay, CJ O’Connor, F Zhang, C Galvagnion, WRJD Galloway, ...
Scientific reports 6 (1), 23732, 2016
412016
The use of chlorobenzene as a probe molecule in molecular dynamics simulations
YS Tan, DR Spring, C Abell, C Verma
Journal of chemical information and modeling 54 (7), 1821-1827, 2014
412014
The application of ligand-mapping molecular dynamics simulations to the rational design of peptidic modulators of protein–protein interactions
YS Tan, DR Spring, C Abell, CS Verma
Journal of chemical theory and computation 11 (7), 3199-3210, 2015
402015
A diversity-oriented synthesis strategy enabling the combinatorial-type variation of macrocyclic peptidomimetic scaffolds
A Isidro-Llobet, KH Georgiou, WRJD Galloway, E Giacomini, MR Hansen, ...
Organic & Biomolecular Chemistry 13 (15), 4570-4580, 2015
402015
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