Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells J Krönke, ND Udeshi, A Narla, P Grauman, SN Hurst, M McConkey, ... Science 343 (6168), 301-305, 2014 | 1646 | 2014 |
Selective killing of cancer cells by a small molecule targeting the stress response to ROS L Raj, T Ide, AU Gurkar, M Foley, M Schenone, X Li, NJ Tolliday, ... Nature 475 (7355), 231-234, 2011 | 1163 | 2011 |
DNA‐templated organic synthesis: nature's strategy for controlling chemical reactivity applied to synthetic molecules X Li, DR Liu Angewandte Chemie International Edition 43 (37), 4848-4870, 2004 | 617 | 2004 |
Identifying the proteins to which small-molecule probes and drugs bind in cells SE Ong, M Schenone, AA Margolin, X Li, K Do, MK Doud, DR Mani, ... Proceedings of the National Academy of Sciences 106 (12), 4617-4622, 2009 | 376 | 2009 |
DNA-catalyzed polymerization X Li, ZYJ Zhan, R Knipe, DG Lynn Journal of the American Chemical Society 124 (5), 746-747, 2002 | 216 | 2002 |
Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL Q Wen, B Goldenson, SJ Silver, M Schenone, V Dancik, Z Huang, ... Cell 150 (3), 575-589, 2012 | 158 | 2012 |
Photoaffinity labeling of small-molecule-binding proteins by DNA-templated chemistry. G Li, Y Liu, Y Liu, L Chen, S Wu, Y Liu, X Li Angewandte Chemie 125 (36), 2013 | 117 | 2013 |
Terazosin activates Pgk1 and Hsp90 to promote stress resistance X Chen, C Zhao, X Li, T Wang, Y Li, C Cao, Y Ding, M Dong, L Finci, ... Nature chemical biology 11 (1), 19-25, 2015 | 102 | 2015 |
Translation of DNA into Synthetic N-Acyloxazolidines X Li, ZJ Gartner, BN Tse, DR Liu Journal of the American Chemical Society 126 (16), 5090-5092, 2004 | 97 | 2004 |
Selection of DNA‐Encoded Small Molecule Libraries Against Unmodified and Non‐Immobilized Protein Targets P Zhao, Z Chen, Y Li, D Sun, Y Gao, Y Huang, X Li Angewandte Chemie International Edition 53 (38), 10056-10059, 2014 | 90 | 2014 |
Stereoselectivity in DNA-templated organic synthesis and its origins X Li, DR Liu Journal of the American Chemical Society 125 (34), 10188-10189, 2003 | 85 | 2003 |
DNA-encoded dynamic chemical library and its applications in ligand discovery Y Zhou, C Li, J Peng, L Xie, L Meng, Q Li, J Zhang, XD Li, X Li, X Huang, ... Journal of the American Chemical Society 140 (46), 15859-15867, 2018 | 84 | 2018 |
Future challenges with DNA-encoded chemical libraries in the drug discovery domain G Zhao, Y Huang, Y Zhou, Y Li, X Li Expert Opinion on Drug Discovery 14 (8), 735-753, 2019 | 71 | 2019 |
Recent advances on the encoding and selection methods of DNA-encoded chemical library B Shi, Y Zhou, Y Huang, J Zhang, X Li Bioorganic & medicinal chemistry letters 27 (3), 361-369, 2017 | 68 | 2017 |
Multistep DNA-templated synthesis using a universal template Y Li, P Zhao, M Zhang, X Zhao, X Li Journal of the American Chemical Society 135 (47), 17727-17730, 2013 | 68 | 2013 |
Design, preparation, and selection of DNA-encoded dynamic libraries G Li, W Zheng, Z Chen, Y Zhou, Y Liu, J Yang, Y Huang, X Li Chemical Science 6 (12), 7097-7104, 2015 | 63 | 2015 |
Multivalent photoaffinity probe for labeling small molecule binding proteins G Li, Y Liu, X Yu, X Li Bioconjugate Chemistry 25 (6), 1172-1180, 2014 | 50 | 2014 |
Selection of DNA‐encoded dynamic chemical libraries for direct inhibitor discovery Y Deng, J Peng, F Xiong, Y Song, Y Zhou, J Zhang, FS Lam, C Xie, ... Angewandte Chemie International Edition 59 (35), 14965-14972, 2020 | 43 | 2020 |
Selecting a DNA-encoded chemical library against non-immobilized proteins using a “ligate–cross-link–purify” strategy B Shi, Y Deng, P Zhao, X Li Bioconjugate Chemistry 28 (9), 2293-2301, 2017 | 41 | 2017 |
Identifying cellular targets of small-molecule probes and drugs with biochemical enrichment and SILAC SE Ong, X Li, M Schenone, SL Schreiber, SA Carr Chemical Proteomics: Methods and Protocols, 129-140, 2012 | 36 | 2012 |