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Hermann Clemens Altmeppen
Hermann Clemens Altmeppen
Institute of Neuropathology, University Medical Center Hamburg-Eppendorf
Bestätigte E-Mail-Adresse bei uke.de
Titel
Zitiert von
Zitiert von
Jahr
The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells
J Wenzel, J Lampe, H Müller-Fielitz, R Schuster, M Zille, K Müller, ...
Nature neuroscience 24 (11), 1522-1533, 2021
2022021
Exosomal cellular prion protein drives fibrillization of amyloid beta and counteracts amyloid beta‐mediated neurotoxicity
C Falker, A Hartmann, I Guett, F Dohler, H Altmeppen, C Betzel, ...
Journal of neurochemistry 137 (1), 88-100, 2016
1462016
Postnatal disruption of the disintegrin/metalloproteinase ADAM10 in brain causes epileptic seizures, learning deficits, altered spine morphology, and defective synaptic functions
J Prox, C Bernreuther, H Altmeppen, J Grendel, M Glatzel, R D'Hooge, ...
Journal of Neuroscience 33 (32), 12915-12928, 2013
1382013
LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance
M Rothaug, F Zunke, JR Mazzulli, M Schweizer, H Altmeppen, ...
Proceedings of the National Academy of Sciences 111 (43), 15573-15578, 2014
1362014
Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo
HC Altmeppen, J Prox, B Puig, MA Kluth, C Bernreuther, D Thurm, ...
Molecular neurodegeneration 6, 1-12, 2011
1342011
High molecular mass assemblies of amyloid-β oligomers bind prion protein in patients with Alzheimer’s disease
F Dohler, D Sepulveda-Falla, S Krasemann, H Altmeppen, H Schlüter, ...
Brain 137 (3), 873-886, 2014
1322014
Proteolytic processing of the prion protein in health and disease
HC Altmeppen, B Puig, F Dohler, DK Thurm, C Falker, S Krasemann, ...
American journal of neurodegenerative disease 1 (1), 15, 2012
1262012
Rapid and reliable universal cloning of influenza A virus genes by target-primed plasmid amplification
J Stech, O Stech, A Herwig, H Altmeppen, J Hundt, S Gohrbandt, ...
Nucleic acids research 36 (21), e139-e139, 2008
1152008
The sheddase ADAM10 is a potent modulator of prion disease
HC Altmeppen, J Prox, S Krasemann, B Puig, K Kruszewski, F Dohler, ...
Elife 4, e04260, 2015
932015
Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site
C Schönherr, J Bien, S Isbert, R Wichert, J Prox, H Altmeppen, S Kumar, ...
Molecular neurodegeneration 11, 1-16, 2016
822016
The GPI-anchoring of PrP: implications in sorting and pathogenesis
B Puig, H Altmeppen, M Glatzel
Prion 8 (1), 11-18, 2014
802014
Diverse functions of the prion protein–Does proteolytic processing hold the key?
L Linsenmeier, HC Altmeppen, S Wetzel, B Mohammadi, P Saftig, ...
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1864 (11), 2128-2137, 2017
782017
Activation of the Nipah virus fusion protein in MDCK cells is mediated by cathepsin B within the endosome-recycling compartment
S Diederich, L Sauerhering, M Weis, H Altmeppen, N Schaschke, ...
Journal of virology 86 (7), 3736-3745, 2012
762012
Cellular composition of cerebrospinal fluid in HIV-1 infected and uninfected subjects
EL Ho, R Ronquillo, H Altmeppen, SS Spudich, RW Price, E Sinclair
PloS one 8 (6), e66188, 2013
742013
Roles of endoproteolytic α‐cleavage and shedding of the prion protein in neurodegeneration
HC Altmeppen, J Prox, B Puig, F Dohler, C Falker, S Krasemann, ...
The FEBS journal 280 (18), 4338-4347, 2013
622013
Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein
L Linsenmeier, B Mohammadi, S Wetzel, B Puig, WS Jackson, ...
Molecular neurodegeneration 13, 1-17, 2018
532018
Characterization of brain-derived extracellular vesicles reveals changes in cellular origin after stroke and enrichment of the prion protein with a potential role in cellular …
S Brenna, HC Altmeppen, B Mohammadi, B Rissiek, F Schlink, P Ludewig, ...
Journal of extracellular vesicles 9 (1), 1809065, 2020
522020
In vivo regulation of the A disintegrin and metalloproteinase 10 (ADAM10) by the tetraspanin 15
L Seipold, H Altmeppen, T Koudelka, A Tholey, P Kasparek, R Sedlacek, ...
Cellular and molecular life sciences 75, 3251-3267, 2018
472018
GPI-anchor signal sequence influences PrPC sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice
B Puig, HC Altmeppen, L Linsenmeier, K Chakroun, F Wegwitz, ...
PLoS pathogens 15 (1), e1007520, 2019
442019
Muskelin coordinates PrPC lysosome versus exosome targeting and impacts prion disease progression
FF Heisler, Y Pechmann, I Wieser, HC Altmeppen, L Veenendaal, ...
Neuron 99 (6), 1155-1169. e9, 2018
442018
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