| X-linked IAP is a direct inhibitor of cell-death proteases QL Deveraux, R Takahashi, GS Salvesen, JC Reed Nature 388 (6639), 300-304, 1997 | 2718 | 1997 |
| The c‐IAP‐1 and c‐IAP‐2 proteins are direct inhibitors of specific caspases N Roy, QL Deveraux, R Takahashi, GS Salvesen, JC Reed The EMBO journal, 1997 | 1784 | 1997 |
| A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death Y Suzuki, Y Imai, H Nakayama, K Takahashi, K Takio, R Takahashi Molecular cell 8 (3), 613-621, 2001 | 1512 | 2001 |
| Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis K Yamanaka, SJ Chun, S Boillee, N Fujimori-Tonou, H Yamashita, ... Nature neuroscience 11 (3), 251-253, 2008 | 1298 | 2008 |
| An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin Y Imai, M Soda, H Inoue, N Hattori, Y Mizuno, R Takahashi Cell 105 (7), 891-902, 2001 | 1284 | 2001 |
| Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity Y Imai, M Soda, R Takahashi Journal of Biological Chemistry 275 (46), 35661-35664, 2000 | 937 | 2000 |
| A single BIR domain of XIAP sufficient for inhibiting caspases R Takahashi, Q Deveraux, I Tamm, K Welsh, N Assa-Munt, GS Salvesen, ... Journal of Biological Chemistry 273 (14), 7787-7790, 1998 | 921 | 1998 |
| Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced … Y Suzuki, Y Nakabayashi, R Takahashi Proceedings of the National Academy of Sciences 98 (15), 8662-8667, 2001 | 896 | 2001 |
| Modeling Alzheimer’s disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness T Kondo, M Asai, K Tsukita, Y Kutoku, Y Ohsawa, Y Sunada, K Imamura, ... Cell stem cell 12 (4), 487-496, 2013 | 866 | 2013 |
| Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model T Kikuchi, A Morizane, D Doi, H Magotani, H Onoe, T Hayashi, H Mizuma, ... Nature 548 (7669), 592-596, 2017 | 679 | 2017 |
| Drug screening for ALS using patient-specific induced pluripotent stem cells N Egawa, S Kitaoka, K Tsukita, M Naitoh, K Takahashi, T Yamamoto, ... Science translational medicine 4 (145), 145ra104-145ra104, 2012 | 639 | 2012 |
| CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity Y Imai, M Soda, S Hatakeyama, T Akagi, T Hashikawa, KI Nakayama, ... Molecular cell 10 (1), 55-67, 2002 | 606 | 2002 |
| A rotarod test for evaluation of motor skill learning H Shiotsuki, K Yoshimi, Y Shimo, M Funayama, Y Takamatsu, K Ikeda, ... Journal of neuroscience methods 189 (2), 180-185, 2010 | 591 | 2010 |
| Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition T Yokota, K Sugawara, K Ito, R Takahashi, H Ariga, H Mizusawa Biochemical and biophysical research communications 312 (4), 1342-1348, 2003 | 499 | 2003 |
| Phosphorylation of 4E‐BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila Y Imai, S Gehrke, HQ Wang, R Takahashi, K Hasegawa, E Oota, B Lu The EMBO journal 27 (18), 2432-2443, 2008 | 488 | 2008 |
| Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis M Urushitani, A Sik, T Sakurai, N Nukina, R Takahashi, JP Julien Nature neuroscience 9 (1), 108-118, 2006 | 482 | 2006 |
| Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila Y Yang, I Nishimura, Y Imai, R Takahashi, B Lu Neuron 37 (6), 911-924, 2003 | 447 | 2003 |
| Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling Y Yang, S Gehrke, ME Haque, Y Imai, J Kosek, L Yang, MF Beal, ... Proceedings of the National Academy of Sciences 102 (38), 13670-13675, 2005 | 446 | 2005 |
| Parkinson's disease–associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria S Liu, T Sawada, S Lee, W Yu, G Silverio, P Alapatt, I Millan, A Shen, ... PLoS genetics 8 (3), e1002537, 2012 | 402 | 2012 |
| X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and-7 in distinct modes Y Suzuki, Y Nakabayashi, K Nakata, JC Reed, R Takahashi Journal of Biological Chemistry 276 (29), 27058-27063, 2001 | 354 | 2001 |
