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Sakthi Moorthy
Sakthi Moorthy
Verified email at utoronto.ca
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Year
The pluripotent regulatory circuitry connecting promoters to their long-range interacting elements
S Schoenfelder, M Furlan-Magaril, B Mifsud, F Tavares-Cadete, R Sugar, ...
Genome research 25 (4), 582-597, 2015
4582015
A Sox2 distal enhancer cluster regulates embryonic stem cell differentiation potential
HY Zhou, Y Katsman, NK Dhaliwal, S Davidson, NN Macpherson, ...
Genes & development 28 (24), 2699-2711, 2014
1832014
Enhancers and super-enhancers have an equivalent regulatory role in embryonic stem cells through regulation of single or multiple genes
SD Moorthy, S Davidson, VM Shchuka, G Singh, N Malek-Gilani, ...
Genome research 27 (2), 246-258, 2017
1692017
Kainate receptors coexist in a functional complex with KCC2 and regulate chloride homeostasis in hippocampal neurons
V Mahadevan, JC Pressey, BA Acton, P Uvarov, MY Huang, J Chevrier, ...
Cell reports 7 (6), 1762-1770, 2014
842014
Enhancer–promoter interactions can bypass CTCF-mediated boundaries and contribute to phenotypic robustness
S Chakraborty, N Kopitchinski, Z Zuo, A Eraso, P Awasthi, R Chari, A Mitra, ...
Nature genetics 55 (2), 280-290, 2023
412023
A flexible repertoire of transcription factor binding sites and a diversity threshold determines enhancer activity in embryonic stem cells
G Singh, S Mullany, SD Moorthy, R Zhang, T Mehdi, R Tian, AG Duncan, ...
Genome Research 31 (4), 564-575, 2021
412021
Chromatin dynamics in lineage commitment and cellular reprogramming
VM Shchuka, N Malek-Gilani, G Singh, L Langroudi, NK Dhaliwal, ...
Genes 6 (3), 641-661, 2015
222015
Generating CRISPR/Cas9 mediated monoallelic deletions to study enhancer function in mouse embryonic stem cells
SD Moorthy, JA Mitchell
JoVE (Journal of Visualized Experiments), e53552, 2016
192016
Transcriptional regulation and chromatin architecture maintenance are decoupled functions at the Sox2 locus
T Taylor, N Sikorska, VM Shchuka, S Chahar, C Ji, NN Macpherson, ...
Genes & Development 36 (11-12), 699-717, 2022
152022
Transcriptional enhancers: from prediction to functional assessment on a genome-wide scale
IC Tobias, LE Abatti, SD Moorthy, S Mullany, T Taylor, N Khader, ...
Genome 64 (4), 426-448, 2021
152021
Lymphatic filarial species differentiation using evolutionarily modified tandem repeats: generation of new genetic markers
M Sakthidevi, V Murugan, SL Hoti, P Kaliraj
Infection, Genetics and Evolution 10 (4), 591-594, 2010
92010
Transcriptional regulation and chromatin architecture maintenance are decoupled modular functions at the Sox2 locus
T Taylor, N Sikorska, VM Shchuka, S Chahar, C Ji, NN Macpherson, ...
biorxiv, 2022.02. 09.479674, 2022
32022
Wucherria bancrofti glutathione S-Transferase: Insights into the 2.3 Å resolution X-ray structure and function, a therapeutic target for human lymphatic filariasis
PR Prabhu, SD Moorthy, J Madhumathi, SN Pradhan, M Perbandt, ...
Biochemical and biophysical research communications 505 (4), 979-984, 2018
22018
Functional analysis of a highly conserved abundant larval transcript-2 (alt-2) intron 2 repeat region of lymphatic filarial parasites
M Sakthidevi, SL Hoti, P Kaliraj
Infection, Genetics and Evolution 24, 177-182, 2014
12014
A Proximal Sox2 Enhancer Cluster is Required for the Anterior Regional Identity of Neural Progenitors
IC Tobias, SD Moorthy, VM Shchuka, L Langroudi, ZE Gillespie, ...
bioRxiv, 2023.11. 09.566464, 2023
2023
Supplemental data for: Enhancers and super-enhancers have an equivalent regulatory role in embryonic stem cells through regulation of single or multiple genes
SD Moorthy, S Davidson, VM Shchuka, G Singh, N Malek-Gilani, ...
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