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Inge Verbrugge
Inge Verbrugge
Genmab
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Year
Radiotherapy increases the permissiveness of established mammary tumors to rejection by immunomodulatory antibodies
I Verbrugge, J Hagekyriakou, LL Sharp, M Galli, A West, NM McLaughlin, ...
Cancer research 72 (13), 3163-3174, 2012
2852012
Combination approaches with immune-checkpoint blockade in cancer therapy
M Swart, I Verbrugge, JB Beltman
Frontiers in oncology 6, 233, 2016
1582016
Targeting the MAPK and PI3K pathways in combination with PD1 blockade in melanoma
MA Deken, J Gadiot, ES Jordanova, R Lacroix, M van Gool, P Kroon, ...
Oncoimmunology 5 (12), e1238557, 2016
1392016
Differentiation therapy for the treatment of t (8; 21) acute myeloid leukemia using histone deacetylase inhibitors
M Bots, I Verbrugge, BP Martin, JM Salmon, M Ghisi, A Baker, K Stanley, ...
Blood, The Journal of the American Society of Hematology 123 (9), 1341-1352, 2014
1292014
The CDK9 inhibitor dinaciclib exerts potent apoptotic and antitumor effects in preclinical models of MLL-rearranged acute myeloid leukemia
A Baker, GP Gregory, I Verbrugge, L Kats, JJ Hilton, E Vidacs, EM Lee, ...
Cancer research 76 (5), 1158-1169, 2016
1132016
SnapShot: extrinsic apoptosis pathways
I Verbrugge, RW Johnstone, MJ Smyth
Cell 143 (7), 1192-1192. e2, 2010
932010
Ubiquitination by the Membrane-associated RING-CH-8 (MARCH-8) Ligase Controls Steady-state Cell Surface Expression of Tumor Necrosis Factor-related Apoptosis Inducing Ligand …
B van de Kooij, I Verbrugge, E de Vries, M Gijsen, V Montserrat, C Maas, ...
Journal of Biological Chemistry 288 (9), 6617-6628, 2013
882013
Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population
N Hein, DP Cameron, KM Hannan, NYN Nguyen, CY Fong, J Sornkom, ...
Blood, The Journal of the American Society of Hematology 129 (21), 2882-2895, 2017
842017
Ionizing radiation modulates the TRAIL death-inducing signaling complex, allowing bypass of the mitochondrial apoptosis pathway
I Verbrugge, E De Vries, SWG Tait, EHJ Wissink, H Walczak, M Verheij, ...
Oncogene 27 (5), 574-584, 2008
572008
TRAIL enhances efficacy of radiotherapy in a p53 mutant, Bcl-2 overexpressing lymphoid malignancy
EHJ Wissink, I Verbrugge, SR Vink, MB Schader, U Schaefer, H Walczak, ...
Radiotherapy and Oncology 80 (2), 214-222, 2006
572006
Smac/DIABLO release from mitochondria and XIAP inhibition are essential to limit clonogenicity of Type I tumor cells after TRAIL receptor stimulation
C Maas, I Verbrugge, E de Vries, G Savich, LW Van de Kooij, SWG Tait, ...
Cell Death & Differentiation 17 (10), 1613-1623, 2010
552010
Combining radiotherapy with APO010 in cancer treatment
I Verbrugge, EHJ Wissink, RW Rooswinkel, J Jongsma, N Beltraminelli, ...
Clinical Cancer Research 15 (6), 2031-2038, 2009
462009
Radiotherapy and cisplatin increase immunotherapy efficacy by enabling local and systemic intratumoral T-cell activity
P Kroon, E Frijlink, V Iglesias-Guimarais, A Volkov, MM van Buuren, ...
Cancer Immunology Research 7 (4), 670-682, 2019
442019
Concomitant targeting of programmed death-1 (PD-1) and CD137 improves the efficacy of radiotherapy in a mouse model of human BRAFV600-mutant melanoma
P Kroon, J Gadiot, M Peeters, A Gasparini, MA Deken, H Yagita, M Verheij, ...
Cancer Immunology, Immunotherapy 65, 753-763, 2016
432016
Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells
E Matas-Rico, E Frijlink, I van der Haar Àvila, A Menegakis, M van Zon, ...
Cell reports 37 (7), 2021
422021
The curative outcome of radioimmunotherapy in a mouse breast cancer model relies on mTOR signaling
I Verbrugge, A Gasparini, NM Haynes, J Hagekyriakou, M Galli, ...
Radiation research 182 (2), 219-229, 2014
332014
Radiation and anticancer drugs can facilitate mitochondrial bypass by CD95/Fas via c-FLIP downregulation
I Verbrugge, C Maas, M Heijkoop, M Verheij, J Borst
Cell Death & Differentiation 17 (3), 551-561, 2010
312010
Promises and challenges of anticancer drugs that target the epigenome
I Verbrugge, RW Johnstone, M Bots
Epigenomics 3 (5), 547-565, 2011
262011
Stem cell-derived cardiomyocytes after bone marrow and heart transplantation
RA De Weger, I Verbrugge, AH Bruggink, MM Van Oosterhout, ...
Bone marrow transplantation 41 (6), 563-569, 2007
242007
Enhancing the antitumor effects of radiotherapy with combinations of immunostimulatory antibodies
I Verbrugge, M Galli, MJ Smyth, RW Johnstone, NM Haynes
Oncoimmunology 1 (9), 1629-1631, 2012
132012
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