| Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks WG Lewis, LG Green, F Grynszpan, Z Radić, PR Carlier, P Taylor, ... Angewandte Chemie International Edition 41 (6), 1053-1057, 2002 | 1075 | 2002 |
| Complexes of Alkylene-Linked Tacrine Dimers with Torpedo californica Acetylcholinesterase: Binding of Bis(5)-tacrine Produces a Dramatic Rearrangement in … EH Rydberg, B Brumshtein, HM Greenblatt, DM Wong, D Shaya, ... Journal of Medicinal Chemistry 49 (18), 5491-5500, 2006 | 242 | 2006 |
| Evaluation of short-tether bis-THA AChE inhibitors. A further test of the dual binding site hypothesis PR Carlier, YF Han, ESH Chow, CPL Li, H Wang, TX Lieu, HS Wong, ... Bioorganic & medicinal chemistry 7 (2), 351-357, 1999 | 215 | 1999 |
| Regioselective azide opening of 2, 3-epoxy alcohols by [Ti (Oi-Pr) 2 (N3) 2]: synthesis of. alpha.-amino acids M Caron, PR Carlier, KB Sharpless The Journal of Organic Chemistry 53 (21), 5185-5187, 1988 | 210 | 1988 |
| Heterodimeric tacrine-based acetylcholinesterase inhibitors: investigating ligand− peripheral site interactions PR Carlier, ESH Chow, Y Han, J Liu, JE Yazal, YP Pang Journal of medicinal chemistry 42 (20), 4225-4231, 1999 | 179 | 1999 |
| Novel dimeric acetylcholinesterase inhibitor bis (7)-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors W Li, R Pi, HHN Chan, H Fu, NTK Lee, HW Tsang, Y Pu, DC Chang, C Li, ... Journal of Biological Chemistry 280 (18), 18179-18188, 2005 | 142 | 2005 |
| Acetylcholinesterase complexed with bivalent ligands related to huperzine A: experimental evidence for species-dependent protein− ligand complementarity DM Wong, HM Greenblatt, H Dvir, PR Carlier, YF Han, YP Pang, I Silman, ... Journal of the American Chemical Society 125 (2), 363-373, 2003 | 118 | 2003 |
| Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors PR Carlier, DM Du, Y Han, J Liu, YP Pang Bioorganic & medicinal chemistry letters 9 (16), 2335-2338, 1999 | 116 | 1999 |
| Antiapicoplast and gametocytocidal screening to identify the mechanisms of action of compounds within the malaria box JD Bowman, EF Merino, CF Brooks, B Striepen, PR Carlier, MB Cassera Antimicrobial agents and chemotherapy 58 (2), 811-819, 2014 | 115 | 2014 |
| Memory of chirality: An emerging strategy for asymmetric synthesis H Zhao, DC Hsu, PR Carlier Synthesis 2005 (01), 1-16, 2005 | 110 | 2005 |
| Dimerization of an inactive fragment of huperzine A produces a drug with twice the potency of the natural product PR Carlier, DM Du, YF Han, J Liu, E Perola, ID Williams, YP Pang Angewandte Chemie 112 (10), 1845-1847, 2000 | 102 | 2000 |
| Effects of bis (7)-tacrine, a novel anti-Alzheimer's agent, on rat brain AChE H Wang, PR Carlier, WL Ho, DC Wu, NTK Lee, CPL Li, YP Pang, YF Han Neuroreport 10 (4), 789-793, 1999 | 97 | 1999 |
| Development of bivalent acetylcholinesterase inhibitors as potential therapeutic drugs for Alzheimer's disease DM Du, PR Carlier Current pharmaceutical design 10 (25), 3141-3156, 2004 | 93 | 2004 |
| Structural genomics for drug design against the pathogen Coxiella burnetii MC Franklin, J Cheung, MJ Rudolph, F Burshteyn, M Cassidy, E Gary, ... Proteins: Structure, Function, and Bioinformatics 83 (12), 2124-2136, 2015 | 88 | 2015 |
| Enhanced kinetic resolution and enzyme-like shape selectivity PR Carlier, WS Mungall, G Schroder, KB Sharpless Journal of the American Chemical Society 110 (9), 2978-2979, 1988 | 85 | 1988 |
| Bis (7)-tacrine, a promising anti-Alzheimer's agent, reduces hydrogen peroxide-induced injury in rat pheochromocytoma cells: comparison with tacrine XQ Xiao, NTK Lee, PR Carlier, YP Pang, YF Han Neuroscience letters 290 (3), 197-200, 2000 | 81 | 2000 |
| Synthesis of a potent wide-spectrum serotonin-, norepinephrine-, dopamine-reuptake inhibitor (SNDRI) and a species-selective dopamine-reuptake inhibitor based on the gamma … PR Carlier, MMC Lo, PCK Lo, E Richelson, M Tatsumi, IJ Reynolds, ... Bioorganic & medicinal chemistry letters 8 (5), 487-492, 1998 | 80 | 1998 |
| 6Li/15N NMR-Based Solution Structural Determination of Et2O-and TMEDA-Solvated Lithiophenylacetonitrile and a LiHMDS Mixed Aggregate PR Carlier, BL Lucht, DB Collum Journal of the American Chemical Society 116 (25), 11602-11603, 1994 | 76 | 1994 |
| Enantioselective synthesis of “quaternary” 1, 4-benzodiazepin-2-one scaffolds via memory of chirality PR Carlier, H Zhao, J DeGuzman, PCH Lam Journal of the American Chemical Society 125 (38), 11482-11483, 2003 | 69 | 2003 |
| Recent progress on the synthesis of CF2H-containing derivatives N Levi, D Amir, E Gershonov, Y Zafrani Synthesis 51 (24), 4549-4567, 2019 | 68 | 2019 |
