Programming molecular association and viscoelastic behavior in protein networks LJ Dooling, ME Buck, WB Zhang, DA Tirrell Advanced Materials 28 (23), 4651, 2016 | 115 | 2016 |
Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle Y Xia, CR Pfeifer, K Zhu, J Irianto, D Liu, K Pannell, EJ Chen, LJ Dooling, ... Journal of Cell Biology 218 (8), 2545-2563, 2019 | 79 | 2019 |
Engineering the dynamic properties of protein networks through sequence variation LJ Dooling, DA Tirrell ACS central science 2 (11), 812-819, 2016 | 73 | 2016 |
Tension in fibrils suppresses their enzymatic degradation–A molecular mechanism for ‘use it or lose it’ K Saini, S Cho, LJ Dooling, DE Discher Matrix Biology 85, 34-46, 2020 | 55 | 2020 |
The macrophage checkpoint CD47: SIRPα for recognition of ‘self’cells: from clinical trials of blocking antibodies to mechanobiological fundamentals JC Andrechak, LJ Dooling, DE Discher Philosophical Transactions of the Royal Society B 374 (1779), 20180217, 2019 | 42 | 2019 |
Macrophages show higher levels of engulfment after disruption of cis interactions between CD47 and the checkpoint receptor SIRPα BH Hayes, RK Tsai, LJ Dooling, S Kadu, JY Lee, D Pantano, ... Journal of cell science 133 (5), jcs237800, 2020 | 39 | 2020 |
Intercellular mechanotransduction during multicellular morphodynamics JH Kim, LJ Dooling, AR Asthagiri Journal of The Royal Society Interface 7 (suppl_3), S341-S350, 2010 | 33 | 2010 |
Scaling laws indicate distinct nucleation mechanisms of holes in the nuclear lamina D Deviri, CR Pfeifer, LJ Dooling, IL Ivanovska, DE Discher, SA Safran Nature Physics 15 (8), 823-829, 2019 | 29 | 2019 |
Gaussian curvature dilutes the nuclear lamina, favoring nuclear rupture, especially at high strain rate CR Pfeifer, MP Tobin, S Cho, M Vashisth, LJ Dooling, LL Vazquez, ... Nucleus 13 (1), 130-144, 2022 | 20 | 2022 |
Tissue mechanics coevolves with fibrillar matrisomes in healthy and fibrotic tissues LJ Dooling, K Saini, AA Anlaş, DE Discher Matrix Biology 111, 153-188, 2022 | 13 | 2022 |
Peptide and protein hydrogels LJ Dooling, DA Tirrell Polymeric and Self Assembled Hydrogels: From Fundamental Understanding to …, 2012 | 10 | 2012 |
Cooperative phagocytosis of solid tumours by macrophages triggers durable anti-tumour responses LJ Dooling, JC Andrechak, BH Hayes, S Kadu, W Zhang, R Pan, ... Nature Biomedical Engineering 7, 1081-1096, 2023 | 9 | 2023 |
Inhibiting Tumor Fibrosis and Actomyosin through GPCR activation LJ Dooling, DE Discher Trends in cancer 5 (4), 197-199, 2019 | 7 | 2019 |
Small lipid droplets are rigid enough to indent a nucleus, dilute the lamina, and cause rupture IL Ivanovska, MP Tobin, T Bai, LJ Dooling, DE Discher Journal of Cell Biology 222 (8), e202208123, 2023 | 5 | 2023 |
CD47-SIRPα Checkpoint Disruption in Metastases Requires Tumor-Targeting Antibody for Molecular and Engineered Macrophage Therapies JC Andrechak, LJ Dooling, MP Tobin, W Zhang, BH Hayes, JY Lee, X Jin, ... Cancers 14 (8), 1930, 2022 | 5 | 2022 |
Confinement plus myosin-II suppression maximizes heritable loss of chromosomes, as revealed by live-cell ChReporters BH Hayes, PK Zhu, M Wang, CR Pfeifer, Y Xia, S Phan, JC Andrechak, ... Journal of cell science 136 (11), jcs260753, 2023 | 4 | 2023 |
Cooperative phagocytosis underlies macrophage immunotherapy of solid tumours and initiates a broad anti-tumour IgG response JC Andrechak, LJ Dooling, BH Hayes, S Kadu, W Zhang, R Pan, ... bioRxiv, 2022.01. 01.474150, 2022 | 4 | 2022 |
Titrating CD47 by mismatch CRISPR-interference reveals incomplete repression can eliminate IgG-opsonized tumors but limits induction of antitumor IgG BH Hayes, H Zhu, JC Andrechak, LJ Dooling, DE Discher PNAS nexus 2 (8), pgad243, 2023 | 3 | 2023 |
Chromosomal instability can favor macrophage-mediated immune response and induce a broad, vaccination-like anti-tumor IgG response BH Hayes, M Wang, H Zhu, SH Phan, JC Andrechak, AH Chang, ... bioRxiv, 2023 | 2 | 2023 |
Small, fat-filled lipid droplets remain spherical as they indent a nucleus, dilute the lamina, and cause rupture I Ivanovska, M Tobin, L Dooling, D Discher bioRxiv, 2022.09. 01.506190, 2022 | 2 | 2022 |