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Lawrence Dooling
Lawrence Dooling
Molecular and Cell Biophysics Lab, University of Pennsylvania
Verified email at seas.upenn.edu - Homepage
Title
Cited by
Cited by
Year
Programming molecular association and viscoelastic behavior in protein networks
LJ Dooling, ME Buck, WB Zhang, DA Tirrell
Advanced Materials 28 (23), 4651, 2016
1152016
Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle
Y Xia, CR Pfeifer, K Zhu, J Irianto, D Liu, K Pannell, EJ Chen, LJ Dooling, ...
Journal of Cell Biology 218 (8), 2545-2563, 2019
792019
Engineering the dynamic properties of protein networks through sequence variation
LJ Dooling, DA Tirrell
ACS central science 2 (11), 812-819, 2016
732016
Tension in fibrils suppresses their enzymatic degradation–A molecular mechanism for ‘use it or lose it’
K Saini, S Cho, LJ Dooling, DE Discher
Matrix Biology 85, 34-46, 2020
552020
The macrophage checkpoint CD47: SIRPα for recognition of ‘self’cells: from clinical trials of blocking antibodies to mechanobiological fundamentals
JC Andrechak, LJ Dooling, DE Discher
Philosophical Transactions of the Royal Society B 374 (1779), 20180217, 2019
422019
Macrophages show higher levels of engulfment after disruption of cis interactions between CD47 and the checkpoint receptor SIRPα
BH Hayes, RK Tsai, LJ Dooling, S Kadu, JY Lee, D Pantano, ...
Journal of cell science 133 (5), jcs237800, 2020
392020
Intercellular mechanotransduction during multicellular morphodynamics
JH Kim, LJ Dooling, AR Asthagiri
Journal of The Royal Society Interface 7 (suppl_3), S341-S350, 2010
332010
Scaling laws indicate distinct nucleation mechanisms of holes in the nuclear lamina
D Deviri, CR Pfeifer, LJ Dooling, IL Ivanovska, DE Discher, SA Safran
Nature Physics 15 (8), 823-829, 2019
292019
Gaussian curvature dilutes the nuclear lamina, favoring nuclear rupture, especially at high strain rate
CR Pfeifer, MP Tobin, S Cho, M Vashisth, LJ Dooling, LL Vazquez, ...
Nucleus 13 (1), 130-144, 2022
202022
Tissue mechanics coevolves with fibrillar matrisomes in healthy and fibrotic tissues
LJ Dooling, K Saini, AA Anlaş, DE Discher
Matrix Biology 111, 153-188, 2022
132022
Peptide and protein hydrogels
LJ Dooling, DA Tirrell
Polymeric and Self Assembled Hydrogels: From Fundamental Understanding to …, 2012
102012
Cooperative phagocytosis of solid tumours by macrophages triggers durable anti-tumour responses
LJ Dooling, JC Andrechak, BH Hayes, S Kadu, W Zhang, R Pan, ...
Nature Biomedical Engineering 7, 1081-1096, 2023
92023
Inhibiting Tumor Fibrosis and Actomyosin through GPCR activation
LJ Dooling, DE Discher
Trends in cancer 5 (4), 197-199, 2019
72019
Small lipid droplets are rigid enough to indent a nucleus, dilute the lamina, and cause rupture
IL Ivanovska, MP Tobin, T Bai, LJ Dooling, DE Discher
Journal of Cell Biology 222 (8), e202208123, 2023
52023
CD47-SIRPα Checkpoint Disruption in Metastases Requires Tumor-Targeting Antibody for Molecular and Engineered Macrophage Therapies
JC Andrechak, LJ Dooling, MP Tobin, W Zhang, BH Hayes, JY Lee, X Jin, ...
Cancers 14 (8), 1930, 2022
52022
Confinement plus myosin-II suppression maximizes heritable loss of chromosomes, as revealed by live-cell ChReporters
BH Hayes, PK Zhu, M Wang, CR Pfeifer, Y Xia, S Phan, JC Andrechak, ...
Journal of cell science 136 (11), jcs260753, 2023
42023
Cooperative phagocytosis underlies macrophage immunotherapy of solid tumours and initiates a broad anti-tumour IgG response
JC Andrechak, LJ Dooling, BH Hayes, S Kadu, W Zhang, R Pan, ...
bioRxiv, 2022.01. 01.474150, 2022
42022
Titrating CD47 by mismatch CRISPR-interference reveals incomplete repression can eliminate IgG-opsonized tumors but limits induction of antitumor IgG
BH Hayes, H Zhu, JC Andrechak, LJ Dooling, DE Discher
PNAS nexus 2 (8), pgad243, 2023
32023
Chromosomal instability can favor macrophage-mediated immune response and induce a broad, vaccination-like anti-tumor IgG response
BH Hayes, M Wang, H Zhu, SH Phan, JC Andrechak, AH Chang, ...
bioRxiv, 2023
22023
Small, fat-filled lipid droplets remain spherical as they indent a nucleus, dilute the lamina, and cause rupture
I Ivanovska, M Tobin, L Dooling, D Discher
bioRxiv, 2022.09. 01.506190, 2022
22022
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