| Retinoic acid metabolism blocking agents (RAMBAs) for treatment of cancer and dermatological diseases VCO Njar, L Gediya, P Purushottamachar, P Chopra, TS Vasaitis, ... Bioorganic & medicinal chemistry 14 (13), 4323-4340, 2006 | 205 | 2006 |
| A new simple and high-yield synthesis of suberoylanilide hydroxamic acid and its inhibitory effect alone or in combination with retinoids on proliferation of human prostate … LK Gediya, P Chopra, P Purushottamachar, N Maheshwari, VCO Njar Journal of medicinal chemistry 48 (15), 5047-5051, 2005 | 131 | 2005 |
| Systematic Structure Modifications of Multi-target Prostate Cancer Drug Candidate Galeterone to Produce Novel Androgen Receptor Down-regulating Agents as an Approach to … P Purushottamachar, AM Godbole, LK Gediya, MS Martin, TS Vasaitis, ... Journal of medicinal chemistry 56 (12), 4880–4898, 2013 | 126 | 2013 |
| Galeterone and VNPT55 induce proteasomal degradation of AR/AR-V7, induce significant apoptosis via cytochrome c release and suppress growth of castration resistant prostate … AK Kwegyir-Afful, S Ramalingam, P Purushottamachar, VP Ramamurthy, ... Oncotarget 6 (29), 27440, 2015 | 117 | 2015 |
| Synthesis and biological evaluations of putative metabolically stable analogs of VN/124-1 (TOK-001): head to head anti-tumor efficacy evaluation of VN/124-1 (TOK-001) and … RD Bruno, TS Vasaitis, LK Gediya, P Purushottamachar, AM Godbole, ... Steroids 76 (12), 1268-1279, 2011 | 96 | 2011 |
| Competitive antagonism between the nicotinic allosteric potentiating ligand galantamine and kynurenic acid at α7* nicotinic receptors C Lopes, EFR Pereira, HQ Wu, P Purushottamachar, V Njar, R Schwarcz, ... Journal of Pharmacology and Experimental Therapeutics 322 (1), 48-58, 2007 | 96 | 2007 |
| Improved synthesis of histone deacetylase inhibitors (HDIs)(MS-275 and CI-994) and inhibitory effects of HDIs alone or in combination with RAMBAs or retinoids on growth of … LK Gediya, A Belosay, A Khandelwal, P Purushottamachar, VCO Njar Bioorganic & medicinal chemistry 16 (6), 3352-3360, 2008 | 62 | 2008 |
| Structure-based screen identifies a potent small molecule inhibitor of Stat5a/b with therapeutic potential for prostate cancer and chronic myeloid leukemia Z Liao, L Gu, J Vergalli, SA Mariani, M De Dominici, RK Lokareddy, ... Molecular cancer therapeutics 14 (8), 1777-1793, 2015 | 51 | 2015 |
| Design, Synthesis, and Evaluation of Novel Mutual Prodrugs (Hybrid Drugs) of All-trans-Retinoic Acid and Histone Deacetylase Inhibitors with Enhanced … LK Gediya, A Khandelwal, J Patel, A Belosay, G Sabnis, J Mehta, ... Journal of medicinal chemistry 51 (13), 3895-3904, 2008 | 51 | 2008 |
| Galeterone and VNPT 55 disrupt Mnk‐eIF 4E to inhibit prostate cancer cell migration and invasion AK Kwegyir‐Afful, RD Bruno, P Purushottamachar, FN Murigi, VCO Njar The FEBS journal 283 (21), 3898-3918, 2016 | 45 | 2016 |
| Potent anti-prostate cancer agents derived from a novel androgen receptor down-regulating agent P Purushottamachar, A Khandelwal, TS Vasaitis, RD Bruno, LK Gediya, ... Bioorganic & medicinal chemistry 16 (7), 3519-3529, 2008 | 39 | 2008 |
| First pharmacophore-based identification of androgen receptor down-regulating agents: discovery of potent anti-prostate cancer agents P Purushottamachar, A Khandelwal, P Chopra, N Maheshwari, LK Gediya, ... Bioorganic & medicinal chemistry 15 (10), 3413-3421, 2007 | 35 | 2007 |
| 3D-QSAR of N-myristoyltransferase inhibiting antifungal agents by CoMFA and CoMSIA methods P Purushottamachar, VM Kulkarni Bioorganic & medicinal chemistry 11 (16), 3487-3497, 2003 | 32 | 2003 |
| Transcriptome profiling reveals that VNPP433‐3β, the lead next‐generation galeterone analog inhibits prostate cancer stem cells by downregulating epithelial–mesenchymal … E Thomas, RS Thankan, P Purushottamachar, W Huang, MA Kane, ... Molecular Carcinogenesis 61 (7), 643-654, 2022 | 27 | 2022 |
| Design, synthesis and biological activity of certain 3, 4-disubstituted-5-mercapto-1, 2, 4-triazoles and their hydrazino derivatives RH Udupi, N Srinivasulu, R Varnekar, P Purushottamachar Bulletin of the Korean Chemical Society 28 (12), 2235-2240, 2007 | 25 | 2007 |
| Galeterone and the next generation galeterone analogs, VNPP414 and VNPP433-3β exert potent therapeutic effects in castration-/drug-resistant prostate cancer preclinical models … AK Kwegyir-Afful, S Ramalingam, VP Ramamurthy, P Purushottamachar, ... Cancers 11 (11), 1637, 2019 | 23 | 2019 |
| Identification of novel steroidal androgen receptor degrading agents inspired by galeterone 3β-Imidazole Carbamate P Purushottamachar, AK Kwegyir-Afful, MS Martin, VP Ramamurthy, ... ACS Medicinal Chemistry Letters 7 (7), 708-713, 2016 | 23 | 2016 |
| Development of benzimidazole compounds for cancer therapy P Purushottamachar, S Ramalingam, VC Njar Chemistry and Applications of Benzimidazole and its Derivatives 1, 1-15, 2019 | 21 | 2019 |
| The novel Mnk1/2 degrader and apoptosis inducer VNLG-152 potently inhibits TNBC tumor growth and metastasis S Ramalingam, VP Ramamurthy, LK Gediya, FN Murigi, ... Cancers 11 (3), 299, 2019 | 21 | 2019 |
| Synthesis and biological screening of bridgehead nitrogen heterocycles: Reactions of 4-(N-pyridylcarboxamido)-5-mercapto-3-substituted-1, 2, 4-triazoles RH Udupi, VM Kulkarni, P Purushottamachar, N Srinivasalu Journal of the Indian Chemical Society 79 (4), 381-382, 2002 | 21 | 2002 |
