| Regulation of sterol synthesis in eukaryotes PJ Espenshade, AL Hughes Annu. Rev. Genet. 41, 401-427, 2007 | 640 | 2007 |
| An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast AL Hughes, DE Gottschling Nature 492 (7428), 261-265, 2012 | 549 | 2012 |
| SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast AL Hughes, BL Todd, PJ Espenshade Cell 120 (6), 831-842, 2005 | 366 | 2005 |
| Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes AL Hughes, DW Powell, M Bard, J Eckstein, R Barbuch, AJ Link, ... Cell metabolism 5 (2), 143-149, 2007 | 275 | 2007 |
| Systematic mapping of contact sites reveals tethers and a function for the peroxisome-mitochondria contact N Shai, E Yifrach, CWT van Roermund, N Cohen, C Bibi, L IJlst, ... Nature communications 9 (1), 1761, 2018 | 259 | 2018 |
| The crucial impact of lysosomes in aging and longevity D Carmona-Gutierrez, AL Hughes, F Madeo, C Ruckenstuhl Ageing research reviews 32, 2-12, 2016 | 220 | 2016 |
| Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast BL Todd, EV Stewart, JS Burg, AL Hughes, PJ Espenshade Molecular and cellular biology 26 (7), 2817-2831, 2006 | 206 | 2006 |
| S-phase checkpoint genes safeguard high-fidelity sister chromatid cohesion CD Warren, DM Eckley, MS Lee, JS Hanna, A Hughes, B Peyser, C Jie, ... Molecular biology of the cell 15 (4), 1724-1735, 2004 | 151 | 2004 |
| Cysteine toxicity drives age-related mitochondrial decline by altering iron homeostasis CE Hughes, TK Coody, MY Jeong, JA Berg, DR Winge, AL Hughes Cell 180 (2), 296-310. e18, 2020 | 147 | 2020 |
| Mother-daughter asymmetry of pH underlies aging and rejuvenation in yeast KA Henderson, AL Hughes, DE Gottschling Elife 3, e03504, 2014 | 136 | 2014 |
| Selective sorting and destruction of mitochondrial membrane proteins in aged yeast AL Hughes, CE Hughes, KA Henderson, N Yazvenko, DE Gottschling Elife 5, e13943, 2016 | 128 | 2016 |
| Cobalt chloride, a hypoxia‐mimicking agent, targets sterol synthesis in the pathogenic fungus Cryptococcus neoformans H Lee, CM Bien, AL Hughes, PJ Espenshade, KJ Kwon‐Chung, ... Molecular microbiology 65 (4), 1018-1033, 2007 | 94 | 2007 |
| Insig regulates HMG-CoA reductase by controlling enzyme phosphorylation in fission yeast JS Burg, DW Powell, R Chai, AL Hughes, AJ Link, PJ Espenshade Cell metabolism 8 (6), 522-531, 2008 | 60 | 2008 |
| 4-Methyl sterols regulate fission yeast SREBP-Scap under low oxygen and cell stress AL Hughes, CYS Lee, CM Bien, PJ Espenshade Journal of Biological Chemistry 282 (33), 24388-24396, 2007 | 59 | 2007 |
| A nuclear-based quality control pathway for non-imported mitochondrial proteins VPS Shakya, WA Barbeau, T Xiao, CS Knutson, MH Schuler, AL Hughes Elife 10, e61230, 2021 | 45 | 2021 |
| Mitochondrial-derived compartments facilitate cellular adaptation to amino acid stress MH Schuler, AM English, T Xiao, TJ Campbell, JM Shaw, AL Hughes Molecular cell 81 (18), 3786-3802. e13, 2021 | 39 | 2021 |
| ER–mitochondria contacts promote mitochondrial-derived compartment biogenesis AM English, MH Schuler, T Xiao, B Kornmann, JM Shaw, AL Hughes Journal of Cell Biology 219 (12), 2020 | 38 | 2020 |
| Parallel evolution of Pseudomonas aeruginosa phage resistance and virulence loss in response to phage treatment in vivo and in vitro M Castledine, D Padfield, P Sierocinski, JS Pascual, A Hughes, ... Elife 11, e73679, 2022 | 36 | 2022 |
| Power2: The power of yeast genetics applied to the powerhouse of the cell J Rutter, AL Hughes Trends in Endocrinology & Metabolism 26 (2), 59-68, 2015 | 28 | 2015 |
| ER targeting of non-imported mitochondrial carrier proteins is dependent on the GET pathway T Xiao, VPS Shakya, AL Hughes Life Science Alliance 4 (3), 2021 | 26 | 2021 |
