| Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival BC Özdemir, T Pentcheva-Hoang, JL Carstens, X Zheng, CC Wu, ... Cancer cell 25 (6), 719-734, 2014 | 2429 | 2014 |
| Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer X Zheng, JL Carstens, J Kim, M Scheible, J Kaye, H Sugimoto, CC Wu, ... Nature 527 (7579), 525-530, 2015 | 2130 | 2015 |
| Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis S Lovisa, VS LeBleu, B Tampe, H Sugimoto, K Vadnagara, JL Carstens, ... Nature medicine 21 (9), 998-1009, 2015 | 854 | 2015 |
| Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer JL Carstens, P Correa de Sampaio, D Yang, S Barua, H Wang, A Rao, ... Nature communications 8 (1), 15095, 2017 | 539 | 2017 |
| Identification of functional heterogeneity of carcinoma-associated fibroblasts with distinct IL6-mediated therapy resistance in pancreatic cancer KM McAndrews, Y Chen, JK Darpolor, X Zheng, S Yang, JL Carstens, B Li, ... Cancer discovery 12 (6), 1580-1597, 2022 | 115 | 2022 |
| Low-dose hydralazine prevents fibrosis in a murine model of acute kidney injury–to–chronic kidney disease progression B Tampe, U Steinle, D Tampe, JL Carstens, P Korsten, EM Zeisberg, ... Kidney international 91 (1), 157-176, 2017 | 111 | 2017 |
| Dual reporter genetic mouse models of pancreatic cancer identify an epithelial‐to‐mesenchymal transition‐independent metastasis program Y Chen, VS LeBleu, JL Carstens, H Sugimoto, X Zheng, S Malasi, D Saur, ... EMBO molecular medicine 10 (10), e9085, 2018 | 77 | 2018 |
| Stabilized epithelial phenotype of cancer cells in primary tumors leads to increased colonization of liver metastasis in pancreatic cancer JL Carstens, S Yang, PC De Sampaio, X Zheng, S Barua, KM McAndrews, ... Cell reports 35 (2), 2021 | 55 | 2021 |
| Microenvironment-dependent cues trigger miRNA-regulated feedback loop to facilitate the EMT/MET switch JL Carstens, S Lovisa, R Kalluri The Journal of clinical investigation 124 (4), 1458-1460, 2014 | 45 | 2014 |
| FGFR1–WNT–TGF-β signaling in prostate cancer mouse models recapitulates human reactive stroma JL Carstens, P Shahi, S Van Tsang, B Smith, CJ Creighton, Y Zhang, ... Cancer research 74 (2), 609-620, 2014 | 44 | 2014 |
| Activation of Wnt signaling by chemically induced dimerization of LRP5 disrupts cellular homeostasis P Shahi, D Park, AC Pond, M Seethammagari, SH Chiou, K Cho, ... PloS one 7 (1), e30814, 2012 | 23 | 2012 |
| BMP7 Signaling in TGFBR2-Deficient Stromal Cells Provokes Epithelial Carcinogenesis HP Eikesdal, LM Becker, Y Teng, A Kizu, JL Carstens, K Kanasaki, ... Molecular Cancer Research 16 (10), 1568-1578, 2018 | 7 | 2018 |
| A Novel Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth in Mouse Models of GI Cancer JB Foote, TE Mattox, AB Keeton, X Chen, FT Smith, KL Berry, T Holmes, ... bioRxiv, 2023.05. 17.541233, 2023 | | 2023 |
| Novel Pan-RAS Inhibitor ADT-007 Induces Tumor Regression in Mouse Models of GI Cancer J Foote, TE Mattox, AB Keeton, FT Smith, KL Berry, AB Ward, KJ Yoon, ... | | 2023 |
| Abstract LB322: Antitumor activity of 1st-in-class pan-RAS inhibitor ADT-1004 in mouse models of pancreatic ductal adenocarcinoma YY Maxuitenko, JB Foote, AB Keeton, X Chen, K Berry, K Fadlalla, ... Cancer Research 83 (8_Supplement), LB322-LB322, 2023 | | 2023 |
| Abstract PO-059: Epithelial/mesenchymal identity dictates pancreatic cancer cell metastasis JL Carstens, S Yang, PC de Sampaio, X Zheng, S Barua, KM McAndrews, ... Cancer Research 81 (22_Supplement), PO-059-PO-059, 2021 | | 2021 |
| Epithelial/mesenchymal identity dictates pancreatic cancer cell metastasis. JL Carstens, S Yang, PC de Sampaio, X Zheng, S Barua, KM McAndrews, ... CANCER RESEARCH 81 (22), 41-42, 2021 | | 2021 |
| 4078 Identification of distinct fibroblast populations with unique roles in pancreatic cancer progression and tumor immunity JK Darpolor, X Zheng, S Yang, H Sugimoto, J Carstens, PC de Sampiao, ... Journal of Clinical and Translational Science 4 (s1), 96-96, 2020 | | 2020 |
| Identification of distinct fibroblast populations with unique roles in PDAC progression and tumor immunity. JK Darpolor, X Zheng, S Yang, KM McAndrews, JL Carstens, PE Phillips, ... CANCER IMMUNOLOGY RESEARCH 8 (3), 84-84, 2020 | | 2020 |
| Abstract A108: Identification of distinct fibroblast populations with unique roles in PDAC progression and tumor immunity JK Darpolor, X Zheng, S Yang, KM McAndrews, JL Carstens, PE Phillips, ... Cancer Immunology Research 8 (3_Supplement), A108-A108, 2020 | | 2020 |
