Dynamic interplay between catalytic and lectin domains of GalNAc-transferases modulates protein O-glycosylation E Lira-Navarrete, M de Las Rivas, I Compañón, MC Pallarés, Y Kong, ... Nature communications 6 (1), 6937, 2015 | 98 | 2015 |
Substrate‐Guided Front‐Face Reaction Revealed by Combined Structural Snapshots and Metadynamics for the Polypeptide N‐Acetylgalactosaminyltransferase 2 E Lira‐Navarrete, J Iglesias‐Fernández, WF Zandberg, I Compañón, ... Angewandte Chemie 126 (31), 8345-8349, 2014 | 96 | 2014 |
Deciphering the Non‐Equivalence of Serine and Threonine O‐Glycosylation Points: Implications for Molecular Recognition of the Tn Antigen by an anti‐MUC1 … N Martínez‐Sáez, J Castro‐López, J Valero‐González, D Madariaga, ... Angewandte Chemie International Edition 54 (34), 9830-9834, 2015 | 83 | 2015 |
Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine‐Selective Protein Modification and Charge Modulation MJ Matos, CD Navo, T Hakala, X Ferhati, A Guerreiro, D Hartmann, ... Angewandte Chemie International Edition 58 (20), 6640-6644, 2019 | 68 | 2019 |
Structure-based design of potent tumor-associated antigens: modulation of peptide presentation by single-atom O/S or O/Se substitutions at the glycosidic linkage I Compañón, A Guerreiro, V Mangini, J Castro-López, M Escudero-Casao, ... Journal of the American Chemical Society 141 (9), 4063-4072, 2019 | 65 | 2019 |
Efficient and irreversible antibody–cysteine bioconjugation using carbonylacrylic reagents B Bernardim, MJ Matos, X Ferhati, I Compañón, A Guerreiro, P Akkapeddi, ... Nature Protocols 14 (1), 86-99, 2019 | 63 | 2019 |
Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3 M de Las Rivas, EJ Paul Daniel, Y Narimatsu, I Compañón, K Kato, ... Nature chemical biology 16 (3), 351-360, 2020 | 58 | 2020 |
Oxetane Grafts Installed Site‐Selectively on Native Disulfides to Enhance Protein Stability and Activity In Vivo N Martínez‐Sáez, S Sun, D Oldrini, P Sormanni, O Boutureira, F Carboni, ... Angewandte Chemie International Edition 56 (47), 14963-14967, 2017 | 54 | 2017 |
S-Michael Additions to Chiral Dehydroalanines as an Entry to Glycosylated Cysteines and a Sulfa-Tn Antigen Mimic C Aydillo, I Companon, A Avenoza, JH Busto, F Corzana, JM Peregrina, ... Journal of the American Chemical Society 136 (2), 789-800, 2014 | 51 | 2014 |
Water sculpts the distinctive shapes and dynamics of the tumor-associated carbohydrate Tn antigens: Implications for their molecular recognition IA Bermejo, I Usabiaga, I Compañón, J Castro-López, A Insausti, ... Journal of the American Chemical Society 140 (31), 9952-9960, 2018 | 42 | 2018 |
The use of fluoroproline in MUC1 antigen enables efficient detection of antibodies in patients with prostate cancer VJ Somovilla, IA Bermejo, IS Albuquerque, N Martinez-Saez, ... Journal of the American Chemical Society 139 (50), 18255-18261, 2017 | 42 | 2017 |
The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences M de Las Rivas, E Lira-Navarrete, EJP Daniel, I Compañón, H Coelho, ... Nature communications 8 (1), 1959, 2017 | 41 | 2017 |
Structural and mechanistic insights into the catalytic-domain-mediated short-range glycosylation preferences of GalNAc-T4 M de Las Rivas, EJ Paul Daniel, H Coelho, E Lira-Navarrete, L Raich, ... ACS Central Science 4 (9), 1274-1290, 2018 | 38 | 2018 |
Efficient Amino‐Sulfhydryl Stapling on Peptides and Proteins Using Bifunctional NHS‐Activated Acrylamides MJSA Silva, H Faustino, JAS Coelho, MV Pinto, A Fernandes, ... Angewandte Chemie International Edition 60 (19), 10850-10857, 2021 | 30 | 2021 |
Design of α-S-Neoglycopeptides Derived from MUC1 with a Flexible and Solvent-Exposed Sugar Moiety V Rojas-Ocáriz, I Compañón, C Aydillo, J Castro-Lopez, ... The Journal of Organic Chemistry 81 (14), 5929-5941, 2016 | 24 | 2016 |
Structural Analysis of a GalNAc‐T2 Mutant Reveals an Induced‐Fit Catalytic Mechanism for GalNAc‐Ts M de Las Rivas, H Coelho, A Diniz, E Lira‐Navarrete, I Compañón, ... Chemistry–A European Journal 24 (33), 8382-8392, 2018 | 21 | 2018 |
Structural and mechanistic insights into the cleavage of clustered O-glycan patches-containing glycoproteins by mucinases of the human gut V Taleb, Q Liao, Y Narimatsu, A García-García, I Compañón, RJ Borges, ... Nature communications 13 (1), 4324, 2022 | 19 | 2022 |
Cell‐Penetrating Peptides Containing Fluorescent d‐Cysteines CD Navo, A Asín, E Gómez‐Orte, MI Gutiérrez‐Jiménez, I Compañón, ... Chemistry–A European Journal 24 (31), 7991-8000, 2018 | 17 | 2018 |
Enhanced Permeability and Binding Activity of Isobutylene‐Grafted Peptides S Sun, I Compañón, N Martínez‐Sáez, JD Seixas, O Boutureira, ... ChemBioChem 19 (1), 48-52, 2018 | 17 | 2018 |
Atomic and Specificity Details of Mucin 1 O-Glycosylation Process by Multiple Polypeptide GalNAc-Transferase Isoforms Unveiled by NMR and Molecular Modeling H Coelho, M Rivas, AS Grosso, A Diniz, CO Soares, RA Francisco, ... Jacs Au 2 (3), 631-645, 2022 | 13 | 2022 |