| A SARS-CoV-2 protein interaction map reveals targets for drug repurposing DE Gordon, GM Jang, M Bouhaddou, J Xu, K Obernier, KM White, ... Nature 583 (7816), 459-468, 2020 | 4330 | 2020 |
| Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes BT Staahl, M Benekareddy, C Coulon-Bainier, AA Banfal, SN Floor, ... Nature biotechnology 35 (5), 431-434, 2017 | 339 | 2017 |
| Tunable protein synthesis by transcript isoforms in human cells SN Floor, JA Doudna Elife 5, e10921, 2016 | 291 | 2016 |
| Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor S Iwasaki, SN Floor, NT Ingolia Nature 534 (7608), 558-561, 2016 | 281 | 2016 |
| CRISPR–Cas9 genome editing in human cells occurs via the Fanconi anemia pathway CD Richardson, KR Kazane, SJ Feng, E Zelin, NL Bray, AJ Schäfer, ... Nature genetics 50 (8), 1132-1139, 2018 | 225 | 2018 |
| The translation inhibitor rocaglamide targets a bimolecular cavity between eIF4A and polypurine RNA S Iwasaki, W Iwasaki, M Takahashi, A Sakamoto, C Watanabe, Y Shichino, ... Molecular cell 73 (4), 738-748. e9, 2019 | 153 | 2019 |
| Pathogenic DDX3X mutations impair RNA metabolism and neurogenesis during fetal cortical development AL Lennox, ML Hoye, R Jiang, BL Johnson-Kerner, LA Suit, ... Neuron 106 (3), 404-420. e8, 2020 | 142 | 2020 |
| Widespread translational remodeling during human neuronal differentiation JD Blair, D Hockemeyer, JA Doudna, HS Bateup, SN Floor Cell reports 21 (7), 2005-2016, 2017 | 136 | 2017 |
| mRNA decapping is promoted by an RNA-binding channel in Dcp2 MV Deshmukh, BN Jones, DU Quang-Dang, J Flinders, SN Floor, C Kim, ... Molecular cell 29 (3), 324-336, 2008 | 124 | 2008 |
| Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress S Oh, RA Flynn, SN Floor, J Purzner, L Martin, BT Do, S Schubert, D Vaka, ... Oncotarget 7 (19), 28169, 2016 | 79 | 2016 |
| Autoinhibitory interdomain interactions and subfamily-specific extensions redefine the catalytic core of the human DEAD-box protein DDX3 SN Floor, KJ Condon, D Sharma, E Jankowsky, JA Doudna Journal of Biological Chemistry 291 (5), 2412-2421, 2016 | 77 | 2016 |
| DDX3 depletion represses translation of mRNAs with complex 5′ UTRs L Calviello, S Venkataramanan, KJ Rogowski, E Wyler, K Wilkins, ... Nucleic acids research 49 (9), 5336-5350, 2021 | 70* | 2021 |
| A split active site couples cap recognition by Dcp2 to activation SN Floor, BN Jones, GA Hernandez, JD Gross Nature structural & molecular biology 17 (9), 1096-1101, 2010 | 54 | 2010 |
| SRP RNA controls a conformational switch regulating the SRP–SRP receptor interaction SB Neher, N Bradshaw, SN Floor, JD Gross, P Walter Nature structural & molecular biology 15 (9), 916-923, 2008 | 49 | 2008 |
| DDX3X and DDX3Y are redundant in protein synthesis S Venkataramanan, M Gadek, L Calviello, K Wilkins, SN Floor Rna 27 (12), 1577-1588, 2021 | 44 | 2021 |
| Dual targeting of DDX3 and eIF4A by the translation inhibitor rocaglamide A M Chen, M Asanuma, M Takahashi, Y Shichino, M Mito, K Fujiwara, ... Cell chemical biology 28 (4), 475-486. e8, 2021 | 40 | 2021 |
| Ligand-induced conformational heterogeneity of cytochrome P450 CYP119 identified by 2D NMR spectroscopy with the unnatural amino acid 13C-p-methoxyphenylalanine JN Lampe, SN Floor, JD Gross, CR Nishida, Y Jiang, MJ Trnka, ... Journal of the American Chemical Society 130 (48), 16168-16169, 2008 | 39 | 2008 |
| Interdomain dynamics and coactivation of the mRNA decapping enzyme Dcp2 are mediated by a gatekeeper tryptophan SN Floor, MS Borja, JD Gross Proceedings of the National Academy of Sciences 109 (8), 2872-2877, 2012 | 37 | 2012 |
| Aberrant cortical development is driven by impaired cell cycle and translational control in a DDX3X syndrome model ML Hoye, L Calviello, AJ Poff, NE Ejimogu, CR Newman, MD Montgomery, ... Elife 11, e78203, 2022 | 27 | 2022 |
| PTBP1 mRNA isoforms and regulation of their translation LMA de Tacca, MC Pulos-Holmes, SN Floor, JHD Cate Rna 25 (10), 1324-1336, 2019 | 27 | 2019 |
