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Dolores González
Dolores González
Profesora de Investigación CSIC
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Cited by
Year
3-D QSAR Investigations of the Inhibition of Leishmania major Farnesyl Pyrophosphate Synthase by Bisphosphonates
JM Sanders, AO Gómez, J Mao, GA Meints, EM Van Brussel, A Burzynska, ...
Journal of medicinal chemistry 46 (24), 5171-5183, 2003
1462003
Saturation site-directed mutagenesis of thymidylate synthase.
S Climie, L Ruiz-Perez, D Gonzalez-Pacanowska, P Prapunwattana, ...
Journal of Biological Chemistry 265 (31), 18776-18779, 1990
1191990
Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis
S Orenes Lorente, JCF Rodrigues, C Jiménez Jiménez, ...
Antimicrobial agents and chemotherapy 48 (8), 2937-2950, 2004
1182004
Deoxyuridine triphosphate nucleotidohydrolase as a potential antiparasitic drug target
C Nguyen, G Kasinathan, I Leal-Cortijo, A Musso-Buendia, M Kaiser, ...
Journal of medicinal chemistry 48 (19), 5942-5954, 2005
1142005
Pyridinium-1-yl bisphosphonates are potent inhibitors of farnesyl diphosphate synthase and bone resorption
JM Sanders, Y Song, JMW Chan, Y Zhang, S Jennings, T Kosztowski, ...
Journal of medicinal chemistry 48 (8), 2957-2963, 2005
1072005
Acyclic Nucleoside Analogues as Inhibitors of Plasmodium falciparum dUTPase
C Nguyen, GF Ruda, A Schipani, G Kasinathan, I Leal, A Musso-Buendia, ...
Journal of medicinal chemistry 49 (14), 4183-4195, 2006
1022006
Design, synthesis and evaluation of 2, 4-diaminoquinazolines as inhibitors of trypanosomal and leishmanial dihydrofolate reductase
S Khabnadideh, D Pez, A Musso, R Brun, LMR Pérez, ...
Bioorganic & medicinal chemistry 13 (7), 2637-2649, 2005
932005
High-throughput screening platform for natural product–based drug discovery against 3 neglected tropical diseases: Human african trypanosomiasis, leishmaniasis, and chagas disease
F Annang, G Pérez-Moreno, R García-Hernández, C Cordon-Obras, ...
Journal of biomolecular screening 20 (1), 82-91, 2015
922015
Evaluation of azasterols as anti-parasitics
L Gros, SO Lorente, Jimenez, V Yardley, L Rattray, H Wharton, S Little, ...
Journal of medicinal chemistry 49 (20), 6094-6103, 2006
922006
The Crystal Structure of a Complex of Campylobacter jejuni dUTPase with Substrate Analogue Sheds Light on the Mechanism and Suggests the “Basic Module” for …
OV Moroz, M Harkiolaki, MY Galperin, AA Vagin, ...
Journal of molecular biology 342 (5), 1583-1597, 2004
922004
The crystal structure of Trypanosoma cruzi dUTPase reveals a novel dUTP/dUDP binding fold
M Harkiolaki, EJ Dodson, V Bernier-Villamor, JP Turkenburg, ...
Structure 12 (1), 41-53, 2004
892004
Squalene synthase as a target for Chagas disease therapeutics
N Shang, Q Li, TP Ko, HC Chan, J Li, Y Zheng, CH Huang, F Ren, ...
PLoS pathogens 10 (5), e1004114, 2014
852014
Kinetic Characterization of Squalene Synthase from Trypanosoma cruzi: Selective Inhibition by Quinuclidine Derivatives
M Sealey-Cardona, S Cammerer, S Jones, LM Ruiz-Pérez, R Brun, ...
Antimicrobial agents and chemotherapy 51 (6), 2123-2129, 2007
852007
Phosphonosulfonates Are Potent, Selective Inhibitors of Dehydrosqualene Synthase and Staphyloxanthin Biosynthesis in Staphylococcus aureus
Y Song, FY Lin, F Yin, M Hensler, CA Rodrigues Poveda, D Mukkamala, ...
Journal of medicinal chemistry 52 (4), 976-988, 2009
842009
Isopentenoid synthesis in isolated embryonic Drosophila cells. Farnesol catabolism and omega-oxidation.
D Gonzalez-Pacanowska, B Arison, CM Havel, JA Watson
Journal of Biological Chemistry 263 (3), 1301-1306, 1988
811988
SQ109, a new drug lead for Chagas disease
P Veiga-Santos, K Li, L Lameira, TMU De Carvalho, G Huang, M Galizzi, ...
Antimicrobial agents and chemotherapy 59 (4), 1950-1961, 2015
732015
3-Hydroxy-3-methyl-glutaryl-CoA Reductase inTrypanosoma(Schizotrypanum)cruzi:Subcellular Localization and Kinetic Properties
JL Concepcion, D Gonzalez-Pacanowska, JA Urbina
Archives of biochemistry and biophysics 352 (1), 114-120, 1998
701998
MDN-0104, an Antiplasmodial Betaine Lipid from Heterospora chenopodii
J Martin, G Crespo, V Gonzalez-Menendez, G Perez-Moreno, ...
Journal of natural products 77 (9), 2118-2123, 2014
682014
Mitochondrial localization of the mevalonate pathway enzyme 3-hydroxy-3-methyl-glutaryl-CoA reductase in the Trypanosomatidae
J Pena-Diaz, A Montalvetti, CL Flores, A Constán, R Hurtado-Guerrero, ...
Molecular Biology of the Cell 15 (3), 1356-1363, 2004
642004
The NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cells
CE Requena, G Pérez-Moreno, LM Ruiz-Pérez, AE Vidal, ...
Biochemical Journal 459 (1), 171-180, 2014
582014
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