3-D QSAR Investigations of the Inhibition of Leishmania major Farnesyl Pyrophosphate Synthase by Bisphosphonates JM Sanders, AO Gómez, J Mao, GA Meints, EM Van Brussel, A Burzynska, ... Journal of medicinal chemistry 46 (24), 5171-5183, 2003 | 146 | 2003 |
Saturation site-directed mutagenesis of thymidylate synthase. S Climie, L Ruiz-Perez, D Gonzalez-Pacanowska, P Prapunwattana, ... Journal of Biological Chemistry 265 (31), 18776-18779, 1990 | 119 | 1990 |
Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis S Orenes Lorente, JCF Rodrigues, C Jiménez Jiménez, ... Antimicrobial agents and chemotherapy 48 (8), 2937-2950, 2004 | 118 | 2004 |
Deoxyuridine triphosphate nucleotidohydrolase as a potential antiparasitic drug target C Nguyen, G Kasinathan, I Leal-Cortijo, A Musso-Buendia, M Kaiser, ... Journal of medicinal chemistry 48 (19), 5942-5954, 2005 | 114 | 2005 |
Pyridinium-1-yl bisphosphonates are potent inhibitors of farnesyl diphosphate synthase and bone resorption JM Sanders, Y Song, JMW Chan, Y Zhang, S Jennings, T Kosztowski, ... Journal of medicinal chemistry 48 (8), 2957-2963, 2005 | 107 | 2005 |
Acyclic Nucleoside Analogues as Inhibitors of Plasmodium falciparum dUTPase C Nguyen, GF Ruda, A Schipani, G Kasinathan, I Leal, A Musso-Buendia, ... Journal of medicinal chemistry 49 (14), 4183-4195, 2006 | 102 | 2006 |
Design, synthesis and evaluation of 2, 4-diaminoquinazolines as inhibitors of trypanosomal and leishmanial dihydrofolate reductase S Khabnadideh, D Pez, A Musso, R Brun, LMR Pérez, ... Bioorganic & medicinal chemistry 13 (7), 2637-2649, 2005 | 93 | 2005 |
High-throughput screening platform for natural product–based drug discovery against 3 neglected tropical diseases: Human african trypanosomiasis, leishmaniasis, and chagas disease F Annang, G Pérez-Moreno, R García-Hernández, C Cordon-Obras, ... Journal of biomolecular screening 20 (1), 82-91, 2015 | 92 | 2015 |
Evaluation of azasterols as anti-parasitics L Gros, SO Lorente, Jimenez, V Yardley, L Rattray, H Wharton, S Little, ... Journal of medicinal chemistry 49 (20), 6094-6103, 2006 | 92 | 2006 |
The Crystal Structure of a Complex of Campylobacter jejuni dUTPase with Substrate Analogue Sheds Light on the Mechanism and Suggests the “Basic Module” for … OV Moroz, M Harkiolaki, MY Galperin, AA Vagin, ... Journal of molecular biology 342 (5), 1583-1597, 2004 | 92 | 2004 |
The crystal structure of Trypanosoma cruzi dUTPase reveals a novel dUTP/dUDP binding fold M Harkiolaki, EJ Dodson, V Bernier-Villamor, JP Turkenburg, ... Structure 12 (1), 41-53, 2004 | 89 | 2004 |
Squalene synthase as a target for Chagas disease therapeutics N Shang, Q Li, TP Ko, HC Chan, J Li, Y Zheng, CH Huang, F Ren, ... PLoS pathogens 10 (5), e1004114, 2014 | 85 | 2014 |
Kinetic Characterization of Squalene Synthase from Trypanosoma cruzi: Selective Inhibition by Quinuclidine Derivatives M Sealey-Cardona, S Cammerer, S Jones, LM Ruiz-Pérez, R Brun, ... Antimicrobial agents and chemotherapy 51 (6), 2123-2129, 2007 | 85 | 2007 |
Phosphonosulfonates Are Potent, Selective Inhibitors of Dehydrosqualene Synthase and Staphyloxanthin Biosynthesis in Staphylococcus aureus Y Song, FY Lin, F Yin, M Hensler, CA Rodrigues Poveda, D Mukkamala, ... Journal of medicinal chemistry 52 (4), 976-988, 2009 | 84 | 2009 |
Isopentenoid synthesis in isolated embryonic Drosophila cells. Farnesol catabolism and omega-oxidation. D Gonzalez-Pacanowska, B Arison, CM Havel, JA Watson Journal of Biological Chemistry 263 (3), 1301-1306, 1988 | 81 | 1988 |
SQ109, a new drug lead for Chagas disease P Veiga-Santos, K Li, L Lameira, TMU De Carvalho, G Huang, M Galizzi, ... Antimicrobial agents and chemotherapy 59 (4), 1950-1961, 2015 | 73 | 2015 |
3-Hydroxy-3-methyl-glutaryl-CoA Reductase inTrypanosoma(Schizotrypanum)cruzi:Subcellular Localization and Kinetic Properties JL Concepcion, D Gonzalez-Pacanowska, JA Urbina Archives of biochemistry and biophysics 352 (1), 114-120, 1998 | 70 | 1998 |
MDN-0104, an Antiplasmodial Betaine Lipid from Heterospora chenopodii J Martin, G Crespo, V Gonzalez-Menendez, G Perez-Moreno, ... Journal of natural products 77 (9), 2118-2123, 2014 | 68 | 2014 |
Mitochondrial localization of the mevalonate pathway enzyme 3-hydroxy-3-methyl-glutaryl-CoA reductase in the Trypanosomatidae J Pena-Diaz, A Montalvetti, CL Flores, A Constán, R Hurtado-Guerrero, ... Molecular Biology of the Cell 15 (3), 1356-1363, 2004 | 64 | 2004 |
The NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cells CE Requena, G Pérez-Moreno, LM Ruiz-Pérez, AE Vidal, ... Biochemical Journal 459 (1), 171-180, 2014 | 58 | 2014 |