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Ryoichi Fujiwara
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Expression of UGT1A and UGT2B mRNA in human normal tissues and various cell lines
A Nakamura, M Nakajima, H Yamanaka, R Fujiwara, T Yokoi
Drug Metabolism and Disposition 36 (8), 1461-1464, 2008
3402008
Quantitative analysis of UDP-glucuronosyltransferase (UGT) 1A and UGT2B expression levels in human livers
T Izukawa, M Nakajima, R Fujiwara, H Yamanaka, T Fukami, M Takamiya, ...
Drug Metabolism and Disposition 37 (8), 1759-1768, 2009
2782009
Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus
R Fujiwara, N Nguyen, S Chen, RH Tukey
Proceedings of the National Academy of Sciences 107 (11), 5024-5029, 2010
1202010
Systemic regulation of bilirubin homeostasis: potential benefits of hyperbilirubinemia
R Fujiwara, M Haag, E Schaeffeler, AT Nies, UM Zanger, M Schwab
Hepatology 67 (4), 1609-1619, 2018
1062018
Interactions between human UGT1A1, UGT1A4, and UGT1A6 affect their enzymatic activities
R Fujiwara, M Nakajima, H Yamanaka, M Katoh, T Yokoi
Drug metabolism and disposition 35 (10), 1781-1787, 2007
912007
Effects of coexpression of UGT1A9 on enzymatic activities of human UGT1A isoforms
R Fujiwara, M Nakajima, H Yamanaka, A Nakamura, M Katoh, S Ikushiro, ...
Drug metabolism and disposition 35 (5), 747-757, 2007
872007
Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-κB leads to hyperbilirubinemia
R Fujiwara, S Chen, M Karin, RH Tukey
Gastroenterology 142 (1), 109-118. e2, 2012
692012
Species differences in drug glucuronidation: Humanized UDP-glucuronosyltransferase 1 mice and their application for predicting drug glucuronidation and drug-induced toxicity in …
R Fujiwara, E Yoda, RH Tukey
Drug metabolism and pharmacokinetics 33 (1), 9-16, 2018
662018
Structure and protein–protein interactions of human UDP-glucuronosyltransferases
R Fujiwara, T Yokoi, M Nakajima
Frontiers in pharmacology 7, 225472, 2016
652016
Role of extrahepatic UDP-glucuronosyltransferase 1A1: advances in understanding breast milk-induced neonatal hyperbilirubinemia
R Fujiwara, Y Maruo, S Chen, RH Tukey
Toxicology and applied pharmacology 289 (1), 124-132, 2015
652015
Interactions between human UDP-glucuronosyltransferase (UGT) 2B7 and UGT1A enzymes
R Fujiwara, M Nakajima, S Oda, H Yamanaka, S Ikushiro, T Sakaki, ...
Journal of pharmaceutical sciences 99 (1), 442-454, 2010
632010
N-Glycosylation plays a role in protein folding of human UGT1A9
M Nakajima, T Koga, H Sakai, H Yamanaka, R Fujiwara, T Yokoi
Biochemical pharmacology 79 (8), 1165-1172, 2010
552010
Toxicological evaluation of acyl glucuronides of nonsteroidal anti-inflammatory drugs using human embryonic kidney 293 cells stably expressing human UDP-glucuronosyltransferase …
T Koga, R Fujiwara, M Nakajima, T Yokoi
Drug metabolism and disposition 39 (1), 54-60, 2011
532011
Inhibition of adenosine deaminase (ADA)‐mediated metabolism of cordycepin by natural substances
G Li, I Nakagome, S Hirono, T Itoh, R Fujiwara
Pharmacology research & perspectives 3 (2), e00121, 2015
512015
Product inhibition of UDP-glucuronosyltransferase (UGT) enzymes by UDP obfuscates the inhibitory effects of UGT substrates
R Fujiwara, M Nakajima, H Yamanaka, M Katoh, T Yokoi
Drug metabolism and disposition 36 (2), 361-367, 2008
502008
Importance of UDP-glucuronosyltransferase 1A1 expression in skin and its induction by UVB in neonatal hyperbilirubinemia
K Sumida, M Kawana, E Kouno, T Itoh, S Takano, T Narawa, RH Tukey, ...
Molecular pharmacology 84 (5), 679-686, 2013
482013
Stereoselective glucuronidation of 5-(4′-hydroxyphenyl)-5-phenylhydantoin by human UDP-glucuronosyltransferase (UGT) 1A1, UGT1A9, and UGT2B15: effects of UGT-UGT interactions
M Nakajima, H Yamanaka, R Fujiwara, M Katoh, T Yokoi
Drug metabolism and disposition 35 (9), 1679-1686, 2007
442007
Impact of fatty acids on human UDP-glucuronosyltransferase 1A1 activity and its expression in neonatal hyperbilirubinemia
A Shibuya, T Itoh, RH Tukey, R Fujiwara
Scientific reports 3 (1), 2903, 2013
412013
Expression of human solute carrier family transporters in skin: possible contributor to drug-induced skin disorders
R Fujiwara, S Takenaka, M Hashimoto, T Narawa, T Itoh
Scientific reports 4 (1), 5251, 2014
392014
Expression pattern of human ATP‐binding cassette transporters in skin
S Takenaka, T Itoh, R Fujiwara
Pharmacology research & perspectives 1 (1), 2013
372013
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